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Wbp2 Gene Detail
Summary
  • Symbol
    Wbp2
  • Name
    WW domain binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104709
    NCBI Gene: 22378
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115969399-115977821 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    280 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104709
 protein coding gene Chr11:115969397-115977821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019413
 protein coding gene Chr11:120164736-120174636 (-)
A/J MGP_AJ_G0019382
 protein coding gene Chr11:114913752-114923120 (-)
AKR/J MGP_AKRJ_G0019352
 protein coding gene Chr11:118340491-118351118 (-)
BALB/cJ MGP_BALBcJ_G0019356
 protein coding gene Chr11:115325791-115334275 (-)
C3H/HeJ MGP_C3HHeJ_G0019162
 protein coding gene Chr11:118691279-118700539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019806
 protein coding gene Chr11:123842390-123851190 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017429
 protein coding gene Chr11:111931541-111939878 (-)
CAST/EiJ MGP_CASTEiJ_G0018717
 protein coding gene Chr11:120040541-120052409 (-)
CBA/J MGP_CBAJ_G0019134
 protein coding gene Chr11:128730664-128739030 (-)
DBA/2J MGP_DBA2J_G0019245
 protein coding gene Chr11:114331200-114339586 (-)
FVB/NJ MGP_FVBNJ_G0019237
 protein coding gene Chr11:113844516-113853258 (-)
LP/J MGP_LPJ_G0019315
 protein coding gene Chr11:120544015-120554207 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019270
 protein coding gene Chr11:127827570-127836032 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019844
 protein coding gene Chr11:118996783-119009436 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018274
 protein coding gene Chr11:118750798-118760555 (-)
WSB/EiJ MGP_WSBEiJ_G0018769
 protein coding gene Chr11:118955676-118967671 (-)



Homology
more
  • Human Ortholog
    WBP2, WW domain binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WBP2, WW domain binding protein 2
  • Synonyms
    DFNB107, GRAMD6, WBP-2
  • Links
    NCBI Gene ID: 23558
    neXtProt AC: NX_Q969T9
    UniProt: Q969T9

  • Chr Location
    17q25.1; chr17:75845699-75856507 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WBP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show progressive high-frequency hearing loss, raised auditory brainstem response (ABR) thresholds, reduced ABR amplitudes, swelling of afferent terminals, inner hair cell synapse defects, and altered expression of AMPA receptor subunits and post-synaptic proteins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    224
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034341 Ensembl Gene Model | MGI Sequence Detail 8423 C57BL/6J ±  kb
    transcript ENSMUST00000074628 Ensembl | MGI Sequence Detail 1826 Not Applicable  
    polypeptide ENSMUSP00000074204 Ensembl | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 225
      cDNA 225

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27072
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:27757 Sudol M, et al., Characterization of a novel protein-binding module--the WW domain. FEBS Lett. 1995 Aug 1;369(1):67-71
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory