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Nnat Gene Detail
Summary
  • Symbol
    Nnat
  • Name
    neuronatin
  • Synonyms
    5730414I02Rik, Peg5
  • Feature Type
    protein coding gene
  • IDs
    MGI:104716
    NCBI Gene: 18111
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157401998-157404442 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.40 cM, cytoband H1
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104716
 protein coding gene Chr2:157401936-157404445 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026784
 protein coding gene Chr2:162576006-162578354 (+)
A/J MGP_AJ_G0026750
 protein coding gene Chr2:156075190-156077631 (+)
AKR/J MGP_AKRJ_G0026721
 protein coding gene Chr2:160674063-160676507 (+)
BALB/cJ MGP_BALBcJ_G0026759
 protein coding gene Chr2:156360592-156362940 (+)
C3H/HeJ MGP_C3HHeJ_G0026501
 protein coding gene Chr2:160978182-160980621 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027208
 protein coding gene Chr2:167410634-167413078 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024578
 protein coding gene Chr2:149526921-149529316 (+)
CAST/EiJ MGP_CASTEiJ_G0025963
 protein coding gene Chr2:161330831-161333271 (+)
CBA/J MGP_CBAJ_G0026478
 protein coding gene Chr2:173427527-173429851 (+)
DBA/2J MGP_DBA2J_G0026616
 protein coding gene Chr2:155249121-155251471 (+)
FVB/NJ MGP_FVBNJ_G0026583
 protein coding gene Chr2:153643497-153645939 (+)
LP/J MGP_LPJ_G0026719
 protein coding gene Chr2:162664537-162666893 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026604
 protein coding gene Chr2:177269746-177273123 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027264
 protein coding gene Chr2:160490461-160492901 (+)
PWK/PhJ MGP_PWKPhJ_G0025697
 protein coding gene Chr2:154772192-154774766 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025500
 protein coding gene Chr2:159430868-159433308 (+)
WSB/EiJ MGP_WSBEiJ_G0026033
 protein coding gene Chr2:161380560-161385720 (+)



Homology
more
  • Human Ortholog
    NNAT, neuronatin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NNAT, neuronatin
  • Synonyms
    Peg5
  • Links
    NCBI Gene ID: 4826
    neXtProt AC: NX_Q16517
    UniProt: Q16517

  • Chr Location
    20q11.23; chr20:37521206-37523690 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for a targeted mutation do not exhibit a detected mutant phenotype. Heterozygous mice with a paternally inherited null allele show impaired glucose-stimulated insulin secretion with islets showing a defect in insulin storage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1344
  • Tissues
    236
  • cDNA Data
    26
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067786 Ensembl Gene Model | MGI Sequence Detail 2445 C57BL/6J ±  kb
    transcript ENSMUST00000088484 Ensembl | MGI Sequence Detail 458 Not Applicable  
    polypeptide ENSMUSP00000085836 Ensembl | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 1
      cDNA 30
      Primer pair 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27079, MGI:2139297, MGI:2442311
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 40
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:29420 Wijnholds J, et al., Segment-specific expression of the neuronatin gene during early hindbrain development. Dev Biol. 1995 Sep;171(1):73-84
    • Latest
      J:350675 Yu V, et al., Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity. Diabetologia. 2024 Jun;67(6):1079-1094
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory