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Sik1 Gene Detail
Summary
  • Symbol
    Sik1
  • Name
    salt inducible kinase 1
  • Synonyms
    Msk, Snf1lk
  • Feature Type
    protein coding gene
  • IDs
    MGI:104754
    NCBI Gene: 17691
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32063224-32074778 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104754
 protein coding gene Chr17:32063222-32074808 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023495
 protein coding gene Chr17:31646499-31661166 (-)
A/J MGP_AJ_G0023452
 protein coding gene Chr17:30604545-30616169 (-)
AKR/J MGP_AKRJ_G0023418
 protein coding gene Chr17:30874020-30885396 (-)
BALB/cJ MGP_BALBcJ_G0023457
 protein coding gene Chr17:30681912-30693194 (-)
C3H/HeJ MGP_C3HHeJ_G0023219
 protein coding gene Chr17:31247077-31260316 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023900
 protein coding gene Chr17:32740117-32752699 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021374
 protein coding gene Chr17:27723394-27734856 (-)
CAST/EiJ MGP_CASTEiJ_G0022720
 protein coding gene Chr17:31285888-31333743 (-)
CBA/J MGP_CBAJ_G0023194
 protein coding gene Chr17:34139480-34153386 (-)
DBA/2J MGP_DBA2J_G0023324
 protein coding gene Chr17:29990129-30001591 (-)
FVB/NJ MGP_FVBNJ_G0023294
 protein coding gene Chr17:29810857-29823094 (-)
LP/J MGP_LPJ_G0023402
 protein coding gene Chr17:31863456-31874793 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023312
 protein coding gene Chr17:33236594-33248076 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023942
 protein coding gene Chr17:31239533-31252962 (-)
PWK/PhJ MGP_PWKPhJ_G0022469
 protein coding gene Chr17:28848649-28880249 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022288
 protein coding gene Chr17:29226010-29237764 (-)
WSB/EiJ MGP_WSBEiJ_G0022782
 protein coding gene Chr17:31211625-31224015 (-)



Homology
more
  • Human Ortholog
    SIK1, salt inducible kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIK1, salt inducible kinase 1
  • Synonyms
    DEE30, MSK, SIK, SIK-1, SIK1B, SNF1LK
  • Links
    NCBI Gene ID: 150094
    neXtProt AC: NX_P57059
    UniProt: P57059

  • Chr Location
    21q22.3; chr21:43414483-43427131 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SIK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele and fed a high fat diet exhibit increased insulin sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1292
  • Tissues
    231
  • cDNA Data
    23
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024042 Ensembl Gene Model | MGI Sequence Detail 11555 C57BL/6J ±  kb
    transcript ENSMUST00000024839 Ensembl | MGI Sequence Detail 4521 Not Applicable  
    polypeptide ENSMUSP00000024839 Ensembl | MGI Sequence Detail 779 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      2.7.11.1
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR034672 Salt-Inducible kinase, catalytic domain
      IPR008271 Serine/threonine-protein kinase, active site
      IPR017090 Serine/threonine-protein kinase, SIK1/2
      IPR015940 Ubiquitin-associated domain
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28045
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 19
      Phenotypes 54
    • Earliest
      J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory