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Tead2 Gene Detail
Summary
  • Symbol
    Tead2
  • Name
    TEA domain family member 2
  • Synonyms
    Etdf, TEAD-2, TEF-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104904
    NCBI Gene: 21677
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44865216-44882892 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.19 cM, cytoband B5
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    507 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104904
 protein coding gene Chr7:44865177-44883068 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032210
 protein coding gene Chr7:45457629-45476871 (+)
A/J MGP_AJ_G0032189
 protein coding gene Chr7:44590524-44608065 (+)
AKR/J MGP_AKRJ_G0032125
 protein coding gene Chr7:45821351-45838798 (+)
BALB/cJ MGP_BALBcJ_G0032201
 protein coding gene Chr7:44590218-44607715 (+)
C3H/HeJ MGP_C3HHeJ_G0031917
 protein coding gene Chr7:46314024-46331234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032693
 protein coding gene Chr7:47724487-47741895 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029707
 protein coding gene Chr7:47153084-47170916 (+)
CAST/EiJ MGP_CASTEiJ_G0031245
 protein coding gene Chr7:37711009-37730156 (+)
CBA/J MGP_CBAJ_G0031881
 protein coding gene Chr7:49293270-49312047 (+)
DBA/2J MGP_DBA2J_G0032039
 protein coding gene Chr7:44263654-44281501 (+)
FVB/NJ MGP_FVBNJ_G0031990
 protein coding gene Chr7:44039799-44057095 (+)
LP/J MGP_LPJ_G0032117
 protein coding gene Chr7:46139789-46159250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032027
 protein coding gene Chr7:48003545-48021684 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032709
 protein coding gene Chr7:45041512-45059781 (+)
PWK/PhJ MGP_PWKPhJ_G0030968
 protein coding gene Chr7:37629274-37647442 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030805
 protein coding gene Chr7:33055122-33072428 (+)
WSB/EiJ MGP_WSBEiJ_G0031362
 protein coding gene Chr7:45533400-45552799 (+)



Homology
more
  • Human Ortholog
    TEAD2, TEA domain transcription factor 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEAD2, TEA domain transcription factor 2
  • Synonyms
    ETF, TEAD-2, TEF-4, TEF4
  • Links
    NCBI Gene ID: 8463
    neXtProt AC: NX_Q15562
    UniProt: Q15562

  • Chr Location
    19q13.33; chr19:49340595-49362457 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a functionally null allele of this gene exhibit no gross abnormalities and are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1381
  • Tissues
    197
  • cDNA Data
    25
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21677 NCBI Gene Model | MGI Sequence Detail 17677 C57BL/6J ±  kb
    transcript NM_001379272 RefSeq | MGI Sequence Detail 2359 ZRU/MplStud  
    polypeptide P48301 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 3
      cDNA 25
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-29058
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 39
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
    • Latest
      J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory