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Glg1 Gene Detail
Summary
  • Symbol
    Glg1
  • Name
    golgi apparatus protein 1
  • Synonyms
    CFR, CFR-1, ESL-1, MG-160, MG160, Selel
  • Feature Type
    protein coding gene
  • IDs
    MGI:104967
    NCBI Gene: 20340
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111881053-111985848 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2023 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104967
 protein coding gene Chr8:111879916-111985848 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034137
 protein coding gene Chr8:113893731-114014537 (-)
A/J MGP_AJ_G0034116
 protein coding gene Chr8:109273482-109380929 (-)
AKR/J MGP_AKRJ_G0034043
 protein coding gene Chr8:112473420-112587208 (-)
BALB/cJ MGP_BALBcJ_G0034110
 protein coding gene Chr8:109448059-109561007 (-)
C3H/HeJ MGP_C3HHeJ_G0033821
 protein coding gene Chr8:113190369-113302641 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034630
 protein coding gene Chr8:117892923-118015004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031572
 protein coding gene Chr8:102249616-102358686 (-)
CAST/EiJ MGP_CASTEiJ_G0033148
 protein coding gene Chr8:112812862-112937587 (-)
CBA/J MGP_CBAJ_G0033795
 protein coding gene Chr8:121899459-122022368 (-)
DBA/2J MGP_DBA2J_G0033950
 protein coding gene Chr8:108560693-108667179 (-)
FVB/NJ MGP_FVBNJ_G0033894
 protein coding gene Chr8:107521286-107630176 (-)
LP/J MGP_LPJ_G0034040
 protein coding gene Chr8:114065183-114184999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033940
 protein coding gene Chr8:124788771-124899544 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034649
 protein coding gene Chr8:112445433-112558622 (-)
PWK/PhJ MGP_PWKPhJ_G0032851
 protein coding gene Chr8:108141176-108254299 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032690
 protein coding gene Chr8:111119664-111272391 (-)
WSB/EiJ MGP_WSBEiJ_G0033264
 protein coding gene Chr8:113123960-113235669 (-)



Homology
more
  • Human Ortholog
    GLG1, golgi glycoprotein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLG1, golgi glycoprotein 1
  • Synonyms
    CFR-1, ESL-1, MG-160, MG160
  • Links
    NCBI Gene ID: 2734
    neXtProt AC: NX_Q92896
    UniProt: Q92896

  • Chr Location
    16q23.1; chr16:74447427-74607144 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show smaller size, narrow rib cages, short and thin bony elements, and reduced chondrocyte proliferation and growth plates. Homozygotes for a gene trap allele show postnatal death, small size, distorted tails and cleft palate. Homozygotes for another gene trap allele die by E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    34
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003316 Ensembl Gene Model | MGI Sequence Detail 104796 C57BL/6J ±  kb
    transcript ENSMUST00000169020 Ensembl | MGI Sequence Detail 7021 Not Applicable  
    polypeptide ENSMUSP00000131355 Ensembl | MGI Sequence Detail 1175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008025 Golgi apparatus protein 1
      (term hierarchy)
    • InterPro Domains
      IPR001893 Cysteine-rich Golgi apparatus protein 1 repeat
      IPR017873 Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote
      IPR039728 Golgi apparatus protein 1
    • GlyGen
      Q61543 6 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 1
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-31040, MGI:2142586, MGI:2142794
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:25676 Steegmaier M, et al., The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature. 1995 Feb 16;373(6515):615-20
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory