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Ddx5 Gene Detail
Summary
  • Symbol
    Ddx5
  • Name
    DEAD box helicase 5
  • Synonyms
    2600009A06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, Hlr1, p68
  • Feature Type
    protein coding gene
  • IDs
    MGI:105037
    NCBI Gene: 13207
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106671181-106680011 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.01 cM, cytoband E2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105037
 protein coding gene Chr11:106671181-106680011 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019313
 protein coding gene Chr11:110115267-110126015 (-)
A/J MGP_AJ_G0019281
 protein coding gene Chr11:105412400-105421990 (-)
AKR/J MGP_AKRJ_G0019250
 protein coding gene Chr11:108555653-108564270 (-)
BALB/cJ MGP_BALBcJ_G0019255
 protein coding gene Chr11:105827279-105838053 (-)
C3H/HeJ MGP_C3HHeJ_G0019064
 protein coding gene Chr11:108850399-108859637 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019705
 protein coding gene Chr11:113516131-113526730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017329
 protein coding gene Chr11:102684730-102689858 (-)
CAST/EiJ MGP_CASTEiJ_G0018617
 protein coding gene Chr11:109938909-109946931 (-)
CBA/J MGP_CBAJ_G0019033
 protein coding gene Chr11:118219231-118228259 (-)
DBA/2J MGP_DBA2J_G0019145
 protein coding gene Chr11:104881815-104891555 (-)
FVB/NJ MGP_FVBNJ_G0019136
 protein coding gene Chr11:104397173-104405675 (-)
LP/J MGP_LPJ_G0019215
 protein coding gene Chr11:110565127-110574075 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019166
 protein coding gene Chr11:117459404-117470176 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019742
 protein coding gene Chr11:109073737-109084042 (-)
PWK/PhJ MGP_PWKPhJ_G0018382
 protein coding gene Chr11:105997818-106006910 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018173
 protein coding gene Chr11:108847728-108857435 (-)
WSB/EiJ MGP_WSBEiJ_G0018668
 protein coding gene Chr11:109050111-109059696 (-)



Homology
more
  • Human Ortholog
    DDX5, DEAD-box helicase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX5, DEAD-box helicase 5
  • Synonyms
    G17P1, HLR1, HUMP68, p68
  • Links
    NCBI Gene ID: 1655
    neXtProt AC: NX_P17844
    UniProt: P17844

  • Chr Location
    17q23.3; chr17:64498254-64508199 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter/null allele die around E11.5 displaying blood vessel malformations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    100
  • cDNA Data
    27
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13207 NCBI Gene Model | MGI Sequence Detail 8831 C57BL/6J ±  kb
    transcript NM_001355676 RefSeq | MGI Sequence Detail 3719 Not Specified  
    polypeptide Q61656 UniProt | EBI | MGI Sequence Detail 614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16216, MGD-MRK-32076, MGI:1919368
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 10
      Gene Ontology 19
      Phenotypes 18
    • Earliest
      J:9938 Iggo R, et al., Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6211-4
    • Latest
      J:351707 Wen C, et al., MCM8 interacts with DDX5 to promote R-loop resolution. EMBO J. 2024 Jul;43(14):3044-3071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory