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Slc9a4 Gene Detail
Summary
  • Symbol
    Slc9a4
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 4
  • Synonyms
    D730009J23Rik, NHE4
  • Feature Type
    protein coding gene
  • IDs
    MGI:105074
    NCBI Gene: 110895
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:40619241-40669885 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 19.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1477 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105074
 protein coding gene Chr1:40619146-40670188 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015970
 protein coding gene Chr1:39376860-39435883 (+)
A/J MGP_AJ_G0015954
 protein coding gene Chr1:38268385-38319303 (+)
AKR/J MGP_AKRJ_G0015909
 protein coding gene Chr1:38738293-38788643 (+)
BALB/cJ MGP_BALBcJ_G0015908
 protein coding gene Chr1:37925330-37975747 (+)
C3H/HeJ MGP_C3HHeJ_G0015741
 protein coding gene Chr1:39047184-39102165 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016361
 protein coding gene Chr1:41005707-41075135 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014083
 protein coding gene Chr1:35185079-35234884 (+)
CAST/EiJ MGP_CASTEiJ_G0015322
 protein coding gene Chr1:38941609-38994319 (+)
CBA/J MGP_CBAJ_G0015713
 protein coding gene Chr1:42211449-42277284 (+)
DBA/2J MGP_DBA2J_G0015814
 protein coding gene Chr1:37549926-37601749 (+)
FVB/NJ MGP_FVBNJ_G0015816
 protein coding gene Chr1:37085363-37140088 (+)
LP/J MGP_LPJ_G0015884
 protein coding gene Chr1:39715220-39772467 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015836
 protein coding gene Chr1:44212799-44269537 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016408
 protein coding gene Chr1:38902494-38958469 (+)
PWK/PhJ MGP_PWKPhJ_G0015105
 protein coding gene Chr1:37355793-37417292 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014887
 protein coding gene Chr1:38873075-38927085 (+)
WSB/EiJ MGP_WSBEiJ_G0015384
 protein coding gene Chr1:38873881-38931649 (+)



Homology
more
  • Human Ortholog
    SLC9A4, solute carrier family 9 member A4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A4, solute carrier family 9 member A4
  • Synonyms
    NHE4
  • Links
    NCBI Gene ID: 389015
    neXtProt AC: NX_Q6AI14
    UniProt: Q6AI14

  • Chr Location
    2q12.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display normal growth and survival but have gastric secretions with reduced acidity, mild gastric necrosis and apoptosis, and abnormal gastric mucosa with reduced numbers of parietal and chief cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    865
  • Tissues
    141
  • cDNA Data
    16
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026065 Ensembl Gene Model | MGI Sequence Detail 50645 C57BL/6J ±  kb
    transcript ENSMUST00000027233 Ensembl | MGI Sequence Detail 3962 Not Applicable  
    polypeptide ENSMUSP00000027233 Ensembl | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-32114, MGI:2138630, MGI:2443484
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:31188 Pathak BG, et al., Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996 Jan 15;31(2):261-3
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory