Gpx3 MGI Mouse Gene Detail - MGI:105102 - glutathione peroxidase 3

Symbol

Gpx3
Name

glutathione peroxidase 3
Synonyms

EGPx, extracellular GPx, GPx, plasma GPx

Feature Type

protein coding gene
IDs

MGI:105102
NCBI Gene: 14778
Alliance

gene page
Transcription Start Sites

36 TSS

Sequence Map

Chr11:54793680-54801213 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM, cytoband B3-B5
Mapping Data

3 experiments

SNPs within 2kb

276 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105102	protein coding gene	Chr11:54793279-54801213 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018321	protein coding gene	Chr11:54393790-54401731 (+)
A/J	MGP_AJ_G0018290	protein coding gene	Chr11:52367762-52375770 (+)
AKR/J	MGP_AKRJ_G0018259	protein coding gene	Chr11:54083828-54091752 (+)
BALB/cJ	MGP_BALBcJ_G0018261	protein coding gene	Chr11:52711532-52719456 (+)
C3H/HeJ	MGP_C3HHeJ_G0018072	protein coding gene	Chr11:54021682-54029609 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018713	protein coding gene	Chr11:56056015-56063939 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016363	protein coding gene	Chr11:49803555-49811467 (+)
CAST/EiJ	MGP_CASTEiJ_G0017637	protein coding gene	Chr11:54063741-54071598 (+)
CBA/J	MGP_CBAJ_G0018047	protein coding gene	Chr11:58714072-58722013 (+)
DBA/2J	MGP_DBA2J_G0018156	protein coding gene	Chr11:52073223-52081158 (+)
FVB/NJ	MGP_FVBNJ_G0018148	protein coding gene	Chr11:51727753-51735664 (+)
LP/J	MGP_LPJ_G0018231	protein coding gene	Chr11:54847344-54855269 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018174	protein coding gene	Chr11:59925931-59933868 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018755	protein coding gene	Chr11:54094959-54102896 (+)
PWK/PhJ	MGP_PWKPhJ_G0017410	protein coding gene	Chr11:52616712-52624744 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017205	protein coding gene	Chr11:53887989-53895919 (+)
WSB/EiJ	MGP_WSBEiJ_G0017685	protein coding gene	Chr11:53741458-53749384 (+)

Human Ortholog

GPX3, glutathione peroxidase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPX3, glutathione peroxidase 3
Synonyms

GPx-P, GSHPx-3, GSHPx-P
Links

HGNC:4555

NCBI Gene ID: 2878

neXtProt AC: NX_P22352

UniProt: P22352
Chr Location

5q33.1; chr5:151020591-151028988 (+) GRCh38

MGI Vertebrate Homology

Gpx3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPX3
Protein SuperFamily

Glutathion_perox
Gene Tree

Gpx3

Diseases

13 with human GPX3 associations

				Human Disease	Mouse Models
				Barrett's adenocarcinoma IDs Barrett's adenocarcinoma DOID:7941 NCI:C7027 UMLS_CUI:C1332460
				Barrett's esophagus IDs Barrett's esophagus DOID:9206 EFO:0000280 ICD10CM:K22.7 ICD9CM:530.85 MESH:D001471 NCI:C2891 OMIM:614266 UMLS_CUI:C0004763
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				congenital heart disease IDs congenital heart disease DOID:1682 ICD10CM:Q24.9 ICD9CM:746.9 MESH:D006330 NCI:C34666 UMLS_CUI:C0018798
				esophageal cancer IDs esophageal cancer DOID:5041 DOID:10291 DOID:10292 DOID:10448 DOID:1102 DOID:1104 ICD10CM:C15.3 ICD10CM:C15.4 ICD10CM:C15.5 ICD9CM:150.2 ICD9CM:150.3 ICD9CM:150.4 ICD9CM:150.5 ICD9CM:150.8 MESH:D004938 NCI:C3028 NCI:C3533 NCI:C3534 NCI:C3535 NCI:C4764 OMIM:133239 UMLS_CUI:C0014859 UMLS_CUI:C0153413 UMLS_CUI:C0153414 UMLS_CUI:C0153415 UMLS_CUI:C0153416 UMLS_CUI:C0496775
				esophagus adenocarcinoma IDs esophagus adenocarcinoma DOID:4914 MESH:C562730 NCI:C4025 UMLS_CUI:C0279628
				esophagus squamous cell carcinoma IDs esophagus squamous cell carcinoma DOID:3748 MESH:D000077277 NCI:C4024 UMLS_CUI:C0279626
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				rectum cancer IDs rectum cancer DOID:1993 DOID:1989 ICD10CM:C20 ICD9CM:154.1 MESH:D012004 NCI:C7418 NCI:C9382 UMLS_CUI:C0007113 UMLS_CUI:C0949022
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

8
Genomic Mutations

2 involving Gpx3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced glutathione peroxidase activity, increase plasma selenium levels when mice are fed a selenium supplemented diet, and reduced kidney selenium levels regardless of selenium supplementation.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1392
Tissues

385
cDNA Data

1581
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpx3

ZFIN gpx3

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All Sequences

54
RefSeq

4
UniProt

3
CCDS

CCDS24703.1

Ensembl

ENSMUSG00000018339 (Evidence)
NCBI Gene

14778

			Length	Strain/Species	Flank
genomic	14778	NCBI Gene Model \| MGI Sequence Detail	7534	C57BL/6J	± kb
transcript	NM_001329860	RefSeq \| MGI Sequence Detail	1637	C57BL/6
polypeptide	P46412	UniProt \| EBI \| MGI Sequence Detail	226	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008212 glutathione peroxidase 3

(term hierarchy)
EC

1.11.1.9
InterPro Domains

IPR000889 Glutathione peroxidase

IPR029759 Glutathione peroxidase active site

IPR029760 Glutathione peroxidase conserved site

IPR036249 Thioredoxin-like superfamily

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All nucleic 1591

Genomic 1

cDNA 1582

Primer pair 7

Other 1

Microarray probesets 3

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MGD-MRK-32142, MGI:2144058

Summaries

All 83

Developmental Gene Expression 22

Diseases 1

Gene Ontology 8

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101544	Chr11:54792944-54792952 (+)	-732 bp
Tssr101545	Chr11:54793569-54793595 (+)	-98 bp
Tssr101546	Chr11:54793673-54793684 (+)	-1 bp
Tssr101547	Chr11:54793714-54793720 (+)	37 bp
Tssr101548	Chr11:54793725-54793731 (+)	48 bp
Tssr101549	Chr11:54793743-54793758 (+)	71 bp
Tssr101550	Chr11:54794827-54794832 (+)	1,150 bp
Tssr101551	Chr11:54797083-54797091 (+)	3,407 bp
Tssr101552	Chr11:54797113-54797154 (+)	3,454 bp
Tssr101553	Chr11:54797602-54797607 (+)	3,925 bp
Tssr101554	Chr11:54797609-54797619 (+)	3,934 bp
Tssr101555	Chr11:54797653-54797661 (+)	3,977 bp
Tssr101556	Chr11:54797944-54797956 (+)	4,270 bp
Tssr101557	Chr11:54797958-54797986 (+)	4,292 bp
Tssr101558	Chr11:54797993-54798003 (+)	4,318 bp
Tssr101559	Chr11:54798011-54798026 (+)	4,339 bp
Tssr101560	Chr11:54798030-54798072 (+)	4,371 bp
Tssr101561	Chr11:54799361-54799383 (+)	5,692 bp
Tssr101562	Chr11:54799385-54799430 (+)	5,728 bp
Tssr101563	Chr11:54799435-54799442 (+)	5,759 bp
Tssr101564	Chr11:54799449-54799463 (+)	5,776 bp
Tssr101565	Chr11:54799878-54799893 (+)	6,206 bp
Tssr101566	Chr11:54799928-54799939 (+)	6,254 bp
Tssr101567	Chr11:54800289-54800302 (+)	6,616 bp
Tssr101568	Chr11:54800365-54800376 (+)	6,691 bp
Tssr101569	Chr11:54800448-54800459 (+)	6,774 bp
Tssr101570	Chr11:54800470-54800510 (+)	6,810 bp
Tssr101571	Chr11:54800524-54800586 (+)	6,875 bp
Tssr101572	Chr11:54800619-54800630 (+)	6,945 bp
Tssr101573	Chr11:54800656-54800657 (+)	6,977 bp
Tssr101574	Chr11:54800670-54800682 (+)	6,996 bp
Tssr101575	Chr11:54800718-54800729 (+)	7,044 bp
Tssr101576	Chr11:54800732-54800750 (+)	7,061 bp
Tssr101577	Chr11:54800761-54800772 (+)	7,087 bp
Tssr101578	Chr11:54800844-54800857 (+)	7,171 bp
Tssr3503	Chr11:54800941-54800942 (+)	7,262 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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