About   Help   FAQ
Nin Gene Detail
Summary
  • Symbol
    Nin
  • Name
    ninein
  • Synonyms
    3110068G20Rik, mKIAA1565
  • Feature Type
    protein coding gene
  • IDs
    MGI:105108
    NCBI Gene: 18080
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:70058209-70160491 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 28.94 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105108
 protein coding gene Chr12:70058209-70160575 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019806
 protein coding gene Chr12:69737969-69841024 (-)
A/J MGP_AJ_G0019764
 protein coding gene Chr12:67137906-67239078 (-)
AKR/J MGP_AKRJ_G0019740
 protein coding gene Chr12:69148041-69250815 (-)
BALB/cJ MGP_BALBcJ_G0019744
 protein coding gene Chr12:67603432-67704380 (-)
C3H/HeJ MGP_C3HHeJ_G0019550
 protein coding gene Chr12:69620424-69725285 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020196
 protein coding gene Chr12:71965478-72066404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017816
 protein coding gene Chr12:64676517-64777305 (-)
CAST/EiJ MGP_CASTEiJ_G0019101
 protein coding gene Chr12:64366666-64473937 (-)
CBA/J MGP_CBAJ_G0019519
 protein coding gene Chr12:74636016-74751205 (-)
DBA/2J MGP_DBA2J_G0019635
 protein coding gene Chr12:67052557-67153107 (-)
FVB/NJ MGP_FVBNJ_G0019622
 protein coding gene Chr12:65950450-66053167 (-)
LP/J MGP_LPJ_G0019707
 protein coding gene Chr12:69699064-69810130 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019661
 protein coding gene Chr12:77932052-78037149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020231
 protein coding gene Chr12:68632023-68732510 (-)
PWK/PhJ MGP_PWKPhJ_G0018866
 protein coding gene Chr12:61318707-61421154 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018661
 protein coding gene Chr12:63010632-63111934 (-)
WSB/EiJ MGP_WSBEiJ_G0019152
 protein coding gene Chr12:69261444-69366429 (-)



Homology
more
  • Human Ortholog
    NIN, ninein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NIN, ninein
  • Synonyms
    SCKL7
  • Links
    NCBI Gene ID: 51199
    neXtProt AC: NX_Q8N4C6
    UniProt: Q8N4C6

  • Chr Location
    14q22.1; chr14:50719763-50831503 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NIN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial pre- and postnatal lethality, thinner skin, delayed skin barrier formation, impaired skin barrier function, impaired differentiation of suprabasal cells, and defects in mitotic spindle orientation, desmosome assembly and lamellar body secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1379
  • Tissues
    71
  • cDNA Data
    119
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021068 Ensembl Gene Model | MGI Sequence Detail 102283 C57BL/6J ±  kb
    transcript ENSMUST00000222237 Ensembl | MGI Sequence Detail 9919 Not Applicable  
    polypeptide ENSMUSP00000152240 Ensembl | MGI Sequence Detail 2113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 119
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-32148, MGI:1920448, MGI:2144801, MGI:2144962
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 17
      Gene Ontology 23
      Phenotypes 10
    • Earliest
      J:31172 Bouckson-Castaing V, et al., Molecular characterisation of ninein, a new coiled-coil protein of the centrosome. J Cell Sci. 1996 Jan;109(Pt 1):179-90
    • Latest
      J:345633 Langner E, et al., Cep120 is essential for kidney stromal progenitor cell growth and differentiation. EMBO Rep. 2024 Jan;25(1):428-454
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory