About   Help   FAQ
Rad23b Gene Detail
Summary
  • Symbol
    Rad23b
  • Name
    RAD23 homolog B, nucleotide excision repair protein
  • Synonyms
    0610007D13Rik, mHR23B
  • Feature Type
    protein coding gene
  • IDs
    MGI:105128
    NCBI Gene: 19359
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:55350043-55392237 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 29.70 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    922 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105128
 protein coding gene Chr4:55350042-55392237 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028305
 protein coding gene Chr4:54053198-54098344 (+)
A/J MGP_AJ_G0028266
 protein coding gene Chr4:51973670-52017353 (+)
AKR/J MGP_AKRJ_G0028215
 protein coding gene Chr4:53386842-53430149 (+)
BALB/cJ MGP_BALBcJ_G0028285
 protein coding gene Chr4:52140617-52183748 (+)
C3H/HeJ MGP_C3HHeJ_G0028006
 protein coding gene Chr4:53915931-53961426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028726
 protein coding gene Chr4:56000370-56047791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026034
 protein coding gene Chr4:48848364-48892402 (+)
CAST/EiJ MGP_CASTEiJ_G0027444
 protein coding gene Chr4:53606336-53653042 (+)
CBA/J MGP_CBAJ_G0027971
 protein coding gene Chr4:57911052-57959048 (+)
DBA/2J MGP_DBA2J_G0028121
 protein coding gene Chr4:51903354-51947754 (+)
FVB/NJ MGP_FVBNJ_G0028088
 protein coding gene Chr4:51129796-51172051 (+)
LP/J MGP_LPJ_G0028220
 protein coding gene Chr4:54143080-54189141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028112
 protein coding gene Chr4:61113907-61161308 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028762
 protein coding gene Chr4:53601463-53646620 (+)
PWK/PhJ MGP_PWKPhJ_G0027169
 protein coding gene Chr4:51881266-51922113 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026997
 protein coding gene Chr4:52886619-52928846 (+)
WSB/EiJ MGP_WSBEiJ_G0027522
 protein coding gene Chr4:53518078-53565185 (+)



Homology
more
  • Human Ortholog
    RAD23B, RAD23 homolog B, nucleotide excision repair protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD23B, RAD23 homolog B, nucleotide excision repair protein
  • Synonyms
    HHR23B, HR23B, P58
  • Links
    NCBI Gene ID: 5887
    neXtProt AC: NX_P54727
    UniProt: P54727

  • Chr Location
    9q31.2; chr9:107283137-107332194 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene usually die around the time of birth. Those that survive show growth retardation, eye, reproductive, behavioral, and digestive system abnormalities. They usually die within 1 year of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    38
  • cDNA Data
    202
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028426 Ensembl Gene Model | MGI Sequence Detail 42195 C57BL/6J ±  kb
    transcript ENSMUST00000030134 Ensembl | MGI Sequence Detail 3810 Not Applicable  
    polypeptide ENSMUSP00000030134 Ensembl | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 206
      Genomic 1
      cDNA 203
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-32169, MGI:1925602, MGI:2140506
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:30878 van der Spek PJ, et al., Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23. Genomics. 1996 Jan 1;31(1):20-7
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory