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Tfap2c Gene Detail
Summary
  • Symbol
    Tfap2c
  • Name
    transcription factor AP-2, gamma
  • Synonyms
    Ap-2.2, AP2gamma, Stra2, Tcfap2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:106032
    NCBI Gene: 21420
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172391513-172400542 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 94.87 cM, cytoband H3-H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106032
 protein coding gene Chr2:172387599-172400542 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026948
 protein coding gene Chr2:178738634-178749261 (+)
A/J MGP_AJ_G0026915
 protein coding gene Chr2:171248940-171258342 (+)
AKR/J MGP_AKRJ_G0026886
 protein coding gene Chr2:176418679-176426730 (+)
BALB/cJ MGP_BALBcJ_G0026924
 protein coding gene Chr2:171647239-171655991 (+)
C3H/HeJ MGP_C3HHeJ_G0026666
 protein coding gene Chr2:176778493-176779895 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027371
 protein coding gene Chr2:183896352-183910162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024741
 protein coding gene Chr2:164497703-164506651 (+)
CAST/EiJ MGP_CASTEiJ_G0026124
 protein coding gene Chr2:177459015-177470671 (+)
CBA/J MGP_CBAJ_G0026643
 protein coding gene Chr2:190772165-190773567 (+)
DBA/2J MGP_DBA2J_G0026781
 protein coding gene Chr2:170344453-170354372 (+)
FVB/NJ MGP_FVBNJ_G0026747
 protein coding gene Chr2:168946243-168955656 (+)
LP/J MGP_LPJ_G0026882
 protein coding gene Chr2:178665492-178676387 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026766
 protein coding gene Chr2:193753295-193765971 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027428
 protein coding gene Chr2:176389626-176409029 (+)
PWK/PhJ MGP_PWKPhJ_G0025861
 protein coding gene Chr2:170118979-170128293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025661
 protein coding gene Chr2:175390541-175399430 (+)
WSB/EiJ MGP_WSBEiJ_G0026197
 protein coding gene Chr2:177369105-177382809 (+)



Homology
more
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
  • Synonyms
    AP2-GAMMA, ERF1, hAP-2g, TFAP2G
  • Links
    NCBI Gene ID: 7022
    neXtProt AC: NX_Q92754
    UniProt: Q92754

  • Chr Location
    20q13.31; chr20:56629306-56639283 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    28 phenotypes from multigenic genotypes
    4 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to embryonic growth retardation, failure to establish a normal maternal-embryonic interface, malformed extra-embryonic tissues, and early embryonic lethality due to placental malfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1174
  • Tissues
    300
  • cDNA Data
    107
  • Literature Summary
    74
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028640 Ensembl Gene Model | MGI Sequence Detail 9030 C57BL/6J ±  kb
    transcript ENSMUST00000099058 Ensembl | MGI Sequence Detail 2985 Not Applicable  
    polypeptide ENSMUSP00000096657 Ensembl | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      Genomic 1
      cDNA 109
      Primer pair 10
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33716, MGD-MRK-36502, MGI:107922, MGI:2138767
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 74
      Gene Ontology 16
      Phenotypes 24
    • Earliest
      J:7873 Keitges E, et al., X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature. 1985 May 16-22;315(6016):226-7
    • Latest
      J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory