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Six4 Gene Detail
Summary
  • Symbol
    Six4
  • Name
    sine oculis-related homeobox 4
  • Synonyms
    AREC3, TrexBF
  • Feature Type
    protein coding gene
  • IDs
    MGI:106034
    NCBI Gene: 20474
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:73146383-73160201 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 30.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106034
 protein coding gene Chr12:73146383-73160230 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019833
 protein coding gene Chr12:72974619-72988461 (-)
A/J MGP_AJ_G0019791
 protein coding gene Chr12:70256582-70270627 (-)
AKR/J MGP_AKRJ_G0019766
 protein coding gene Chr12:72381836-72395683 (-)
BALB/cJ MGP_BALBcJ_G0019771
 protein coding gene Chr12:70733920-70747794 (-)
C3H/HeJ MGP_C3HHeJ_G0019576
 protein coding gene Chr12:72808389-72822263 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020223
 protein coding gene Chr12:75252859-75266706 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017841
 protein coding gene Chr12:67707021-67720750 (-)
CAST/EiJ MGP_CASTEiJ_G0019128
 protein coding gene Chr12:67603186-67617589 (-)
CBA/J MGP_CBAJ_G0019546
 protein coding gene Chr12:78107707-78121776 (-)
DBA/2J MGP_DBA2J_G0019662
 protein coding gene Chr12:70147376-70161223 (-)
FVB/NJ MGP_FVBNJ_G0019649
 protein coding gene Chr12:68999963-69013827 (-)
LP/J MGP_LPJ_G0019734
 protein coding gene Chr12:73012006-73025846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019688
 protein coding gene Chr12:81262738-81276570 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020258
 protein coding gene Chr12:71866594-71880441 (-)
PWK/PhJ MGP_PWKPhJ_G0018893
 protein coding gene Chr12:64456834-64470948 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018688
 protein coding gene Chr12:66265406-66288198 (-)
WSB/EiJ MGP_WSBEiJ_G0019179
 protein coding gene Chr12:72456789-72470693 (-)



Homology
more
  • Human Ortholog
    SIX4, SIX homeobox 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIX4, SIX homeobox 4
  • Synonyms
    AREC3
  • Links
    NCBI Gene ID: 51804
    neXtProt AC: NX_Q9UIU6
    UniProt: Q9UIU6

  • Chr Location
    14q23.1; chr14:60709539-60724351 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    33 phenotypes from multigenic genotypes
    31 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Six4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    36 strains or lines available
Homozygotes for a targeted null mutation are viable, fertile, and exhibit no apparent abnormalities suggesting compensation by other Six family members.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    230
  • cDNA Data
    40
  • Literature Summary
    39
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20474 NCBI Gene Model | MGI Sequence Detail 13819 C57BL/6J ±  kb
transcript NM_011382 RefSeq | MGI Sequence Detail 6222 C57BL/6  
polypeptide Q61321 UniProt | EBI | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 41
    Primer pair 4
    Other 4

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33718, MGI:2144757
References
more
  • Summaries
    All 90
    Developmental Gene Expression 39
    Gene Ontology 22
    Phenotypes 31
  • Earliest
    J:31713 Kawakami K, et al., Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 1996 Jan 15;24(2):303-10
  • Latest
    J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory