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Ppm1g Gene Detail
Summary
  • Symbol
    Ppm1g
  • Name
    protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
  • Synonyms
    Fin13
  • Feature Type
    protein coding gene
  • IDs
    MGI:106065
    NCBI Gene: 14208
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31360012-31377889 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106065
 protein coding gene Chr5:31360008-31378031 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029418
 protein coding gene Chr5:29191229-29211342 (-)
A/J MGP_AJ_G0029384
 protein coding gene Chr5:28231850-28250170 (-)
AKR/J MGP_AKRJ_G0029334
 protein coding gene Chr5:29382642-29400462 (-)
BALB/cJ MGP_BALBcJ_G0029395
 protein coding gene Chr5:28747874-28765720 (-)
C3H/HeJ MGP_C3HHeJ_G0029116
 protein coding gene Chr5:29399374-29418827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029848
 protein coding gene Chr5:30997934-31019726 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027086
 protein coding gene Chr5:25698607-25716936 (-)
CAST/EiJ MGP_CASTEiJ_G0028526
 protein coding gene Chr5:28484525-28504109 (-)
CBA/J MGP_CBAJ_G0029084
 protein coding gene Chr5:31568182-31586539 (-)
DBA/2J MGP_DBA2J_G0029233
 protein coding gene Chr5:28410311-28428244 (-)
FVB/NJ MGP_FVBNJ_G0029191
 protein coding gene Chr5:27827026-27845448 (-)
LP/J MGP_LPJ_G0029318
 protein coding gene Chr5:29645873-29665513 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029220
 protein coding gene Chr5:32439702-32457540 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029882
 protein coding gene Chr5:28898221-28918012 (-)
PWK/PhJ MGP_PWKPhJ_G0028251
 protein coding gene Chr5:27532283-27550744 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028081
 protein coding gene Chr5:28284181-28302826 (-)
WSB/EiJ MGP_WSBEiJ_G0028607
 protein coding gene Chr5:28962449-28981335 (-)



Homology
more
  • Human Ortholog
    PPM1G, protein phosphatase, Mg2+/Mn2+ dependent 1G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1G, protein phosphatase, Mg2+/Mn2+ dependent 1G
  • Synonyms
    PP2CG, PP2CGAMMA, PPP2CG
  • Links
    NCBI Gene ID: 5496
    neXtProt AC: NX_O15355
    UniProt: O15355

  • Chr Location
    2p23.3; chr2:27381195-27409591 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppm1g mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    10
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    5 involving Ppm1g
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    26 strains or lines available
Mice homozygous for a targeted mutation display perinatal lethality. Mice heterozygous for a targeted mutation display a decrease in prepulse inhibition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    982
  • Tissues
    161
  • cDNA Data
    188
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14208 NCBI Gene Model | MGI Sequence Detail 17878 C57BL/6J ±  kb
transcript NM_008014 RefSeq | MGI Sequence Detail 2165 ZRU/MplStud  
polypeptide Q61074 UniProt | EBI | MGI Sequence Detail 542 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 192
    Genomic 1
    cDNA 188
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33749, MGI:2140851
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 9
    Phenotypes 31
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory