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Ocln Gene Detail
Summary
  • Symbol
    Ocln
  • Name
    occludin
  • Synonyms
    Ocl
  • Feature Type
    protein coding gene
  • IDs
    MGI:106183
    NCBI Gene: 18260
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100633015-100689226 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 53.23 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1682 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106183
 protein coding gene Chr13:100633012-100689226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020886
 protein coding gene Chr13:102418803-102473949 (-)
A/J MGP_AJ_G0020838
 protein coding gene Chr13:98436688-98493745 (-)
AKR/J MGP_AKRJ_G0020813
 protein coding gene Chr13:101465520-101521572 (-)
BALB/cJ MGP_BALBcJ_G0020837
 protein coding gene Chr13:99169291-99222755 (-)
C3H/HeJ MGP_C3HHeJ_G0020627
 protein coding gene Chr13:101176086-101229607 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021271
 protein coding gene Chr13:105464277-105520332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018842
 protein coding gene Chr13:94272039-94325163 (-)
CAST/EiJ MGP_CASTEiJ_G0020146
 protein coding gene Chr13:100620555-100686208 (-)
CBA/J MGP_CBAJ_G0020588
 protein coding gene Chr13:109623219-109686596 (-)
DBA/2J MGP_DBA2J_G0020713
 protein coding gene Chr13:98223516-98279450 (-)
FVB/NJ MGP_FVBNJ_G0020694
 protein coding gene Chr13:96963905-97017384 (-)
LP/J MGP_LPJ_G0020787
 protein coding gene Chr13:102441528-102495344 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020723
 protein coding gene Chr13:109887009-109943548 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021311
 protein coding gene Chr13:100911579-100972515 (-)
PWK/PhJ MGP_PWKPhJ_G0019899
 protein coding gene Chr13:96934543-96993116 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019721
 protein coding gene Chr13:97142654-97200883 (-)
WSB/EiJ MGP_WSBEiJ_G0020203
 protein coding gene Chr13:101376472-101434899 (-)



Homology
more
  • Human Ortholog
    OCLN, occludin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OCLN, occludin
  • Synonyms
    BLCPMG, PPP1R115, PTORCH1
  • Links
    NCBI Gene ID: 100506658
    neXtProt AC: NX_Q16625
    UniProt: Q16625

  • Chr Location
    chr5:69492292-69558104 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human OCLN associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 4 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display gastritis, loss of gastric parietal and chief cells, gastric mucus cell hyperplasia, reduced gastric acid secretion, growth retardation, male infertility, seminiferous tubule atrophy, failure to nurse pups, mineral deposits in the brain, and thinning of the compact bone.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    980
  • Tissues
    187
  • cDNA Data
    12
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021638 Ensembl Gene Model | MGI Sequence Detail 56212 C57BL/6J ±  kb
    transcript ENSMUST00000069756 Ensembl | MGI Sequence Detail 4052 Not Applicable  
    polypeptide ENSMUSP00000065284 Ensembl | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 8
      cDNA 12
      Primer pair 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33873, MGI:2145262
    References
    more
    • Summaries
      All 211
      Developmental Gene Expression 109
      Diseases 1
      Gene Ontology 28
      Phenotypes 34
    • Earliest
      J:32229 Ando-Akatsuka Y, et al., Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 1996 Apr;133(1):43-7
    • Latest
      J:359191 Lin HH, et al., Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA. Nat Commun. 2024 Dec 3;15(1):10537
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory