About   Help   FAQ
Stfa2 Gene Detail
Summary
  • Symbol
    Stfa2
  • Name
    stefin A2
  • Synonyms
    Stf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106197
    NCBI Gene: 20862
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36224308-36228725 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 25.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106197
 protein coding gene Chr16:36224308-36228819 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022780
 protein coding gene Chr16:34529981-34537223 (+)
A/J MGP_AJ_G0022745
 protein coding gene Chr16:32855105-32860455 (+)
AKR/J MGP_AKRJ_G0022724
 protein coding gene Chr16:34332478-34339716 (-)
BALB/cJ MGP_BALBcJ_G0022747
 protein coding gene Chr16:32975328-32997851 (+)
C3H/HeJ MGP_C3HHeJ_G0022517
 protein coding gene Chr16:34459713-34463808 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0022043
 protein coding gene Chr16:34493630-34494554 (-)
CBA/J MGP_CBAJ_G0022487
 protein coding gene Chr16:37160775-37175475 (-)
DBA/2J MGP_DBA2J_G0022620
 protein coding gene Chr16:32971803-32978354 (-)
FVB/NJ MGP_FVBNJ_G0022590
 protein coding gene Chr16:32670313-32675327 (+)
LP/J MGP_LPJ_G0022688
 protein coding gene Chr16:34485420-34489476 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022609
 protein coding gene Chr16:35994831-36003117 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023208
 protein coding gene Chr16:34070360-34078658 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021612
 protein coding gene Chr16:33870418-33877989 (+)
WSB/EiJ MGP_WSBEiJ_G0022084
 protein coding gene Chr16:33987400-33988226 (+)



Homology
more
  • Human Ortholog
    CSTA, cystatin A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSTA, cystatin A
  • Synonyms
    AREI, PSS4, STF1, STFA
  • Links
    NCBI Gene ID: 1475
    neXtProt AC: NX_P01040
    UniProt: P01040

  • Chr Location
    3q21.1; chr3:122325248-122341969 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CSTA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20862 NCBI Gene Model | MGI Sequence Detail 4418 C57BL/6J ±  kb
transcript NM_001082545 RefSeq | MGI Sequence Detail 423 ZRU/MplStud  
polypeptide P35174 UniProt | EBI | MGI Sequence Detail 103 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-14622, MGD-MRK-33888
References
more
  • Summaries
    All 22
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:11008 Noebels JL, et al., Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures [published erratum appears in Epilepsy Res 1992 Mar;11(1):72]. Epilepsy Res. 1990 Nov;7(2):129-35
  • Latest
    J:283812 Mezzapesa A, et al., Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis. Sci Rep. 2019 Jul 3;9(1):9631
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory