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Tspyl2 Gene Detail
Summary
  • Symbol
    Tspyl2
  • Name
    TSPY-like 2
  • Synonyms
    CINAP, DENTT, DXBwg1396e, DXHXS1008E, E130307F10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:106244
    NCBI Gene: 52808
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:151119848-151125421 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106244
 protein coding gene ChrX:151119847-151125480 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036185
 protein coding gene ChrX:150103017-150108590 (-)
A/J MGP_AJ_G0036161
 protein coding gene ChrX:149289239-149294812 (-)
AKR/J MGP_AKRJ_G0036087
 protein coding gene ChrX:154131200-154136774 (-)
BALB/cJ MGP_BALBcJ_G0036152
 protein coding gene ChrX:147477919-147483492 (-)
C3H/HeJ MGP_C3HHeJ_G0035860
 protein coding gene ChrX:150315542-150321115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036677
 protein coding gene ChrX:154376123-154381696 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033501
 protein coding gene ChrX:140978298-140983882 (-)
CAST/EiJ MGP_CASTEiJ_G0035151
 protein coding gene ChrX:129736995-129742568 (-)
CBA/J MGP_CBAJ_G0035837
 protein coding gene ChrX:158919050-158924623 (-)
DBA/2J MGP_DBA2J_G0035995
 protein coding gene ChrX:148349509-148355082 (-)
FVB/NJ MGP_FVBNJ_G0035929
 protein coding gene ChrX:147485336-147490909 (-)
LP/J MGP_LPJ_G0036086
 protein coding gene ChrX:151206911-151212370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035965
 protein coding gene ChrX:167068393-167073966 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036712
 protein coding gene ChrX:149630372-149635945 (-)
PWK/PhJ MGP_PWKPhJ_G0034845
 protein coding gene ChrX:126673286-126679035 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034671
 protein coding gene ChrX:130190703-130196248 (-)
WSB/EiJ MGP_WSBEiJ_G0035286
 protein coding gene ChrX:147680935-147686509 (-)



Homology
more
  • Human Ortholog
    TSPYL2, TSPY like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPYL2, TSPY like 2
  • Synonyms
    CDA1, CINAP, CTCL, DENTT, HRIHFB2216, NP79, SE204, TSPX
  • Links
    NCBI Gene ID: 64061
    neXtProt AC: NX_Q9H2G4
    UniProt: Q9H2G4

  • Chr Location
    Xp11.22; chrX:53082367-53088540 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for a targeted allele are viable, fertile and do not exhibit increased tumor incidence; however, mutant mouse embryonic fibroblasts are impaired in cell cycle arrest following DNA damage induced by ionizing radiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1285
  • Tissues
    249
  • cDNA Data
    39
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041096 Ensembl Gene Model | MGI Sequence Detail 5574 C57BL/6J ±  kb
transcript ENSMUST00000044509 Ensembl | MGI Sequence Detail 2696 Not Applicable  
polypeptide ENSMUSP00000046782 Ensembl | MGI Sequence Detail 677 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 39
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33936, MGI:1924263, MGI:1926887
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory