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Prpf19 Gene Detail
Summary
  • Symbol
    Prpf19
  • Name
    pre-mRNA processing factor 19
  • Synonyms
    D19Wsu55e, Prp19, PSO4, Snev
  • Feature Type
    protein coding gene
  • IDs
    MGI:106247
    NCBI Gene: 28000
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10872595-10886923 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 7.33 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    430 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106247
 protein coding gene Chr19:10872595-10886923 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024861
 protein coding gene Chr19:8272731-8288930 (+)
A/J MGP_AJ_G0024829
 protein coding gene Chr19:7712124-7726451 (+)
AKR/J MGP_AKRJ_G0024804
 protein coding gene Chr19:8011746-8026074 (+)
BALB/cJ MGP_BALBcJ_G0024829
 protein coding gene Chr19:7756983-7771790 (+)
C3H/HeJ MGP_C3HHeJ_G0024595
 protein coding gene Chr19:7905103-7919437 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025277
 protein coding gene Chr19:8623960-8639771 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022704
 protein coding gene Chr19:8129677-8143780 (+)
CAST/EiJ MGP_CASTEiJ_G0024068
 protein coding gene Chr19:7556553-7570685 (+)
CBA/J MGP_CBAJ_G0024569
 protein coding gene Chr19:8686700-8704599 (+)
DBA/2J MGP_DBA2J_G0024696
 protein coding gene Chr19:7716880-7731216 (+)
FVB/NJ MGP_FVBNJ_G0024663
 protein coding gene Chr19:7763594-7777913 (+)
LP/J MGP_LPJ_G0024783
 protein coding gene Chr19:8223982-8240027 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024690
 protein coding gene Chr19:8571971-8586298 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025325
 protein coding gene Chr19:8034610-8048994 (+)
PWK/PhJ MGP_PWKPhJ_G0023813
 protein coding gene Chr19:7171775-7186130 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023618
 protein coding gene Chr19:7219854-7235776 (+)
WSB/EiJ MGP_WSBEiJ_G0024130
 protein coding gene Chr19:7925990-7940311 (+)



Homology
more
  • Human Ortholog
    PRPF19, pre-mRNA processing factor 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPF19, pre-mRNA processing factor 19
  • Synonyms
    hPSO4, NMP200, PRP19, PSO4, SNEV, UBOX4
  • Links
    NCBI Gene ID: 27339
    neXtProt AC: NX_Q9UMS4
    UniProt: Q9UMS4

  • Chr Location
    11q12.2; chr11:60890547-60906585 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to implantation and have defective cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    20
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28000 NCBI Gene Model | MGI Sequence Detail 14329 C57BL/6J ±  kb
    transcript NM_001253843 RefSeq | MGI Sequence Detail 6218 ZRU/MplStud  
    polypeptide Q99KP6 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33939, MGI:2147181, MGI:2147631
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 9
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:353355 Yao X, et al., BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory