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Cherp Gene Detail
Summary
  • Symbol
    Cherp
  • Name
    calcium homeostasis endoplasmic reticulum protein
  • Synonyms
    5730408I11Rik, D8Wsu96e, DAN16, SCAF6
  • Feature Type
    protein coding gene
  • IDs
    MGI:106417
    NCBI Gene: 27967
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:73214333-73229070 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.08 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106417
 protein coding gene Chr8:73214327-73229077 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033783
 protein coding gene Chr8:72958510-72976166 (-)
A/J MGP_AJ_G0033765
 protein coding gene Chr8:69994518-70009285 (-)
AKR/J MGP_AKRJ_G0033692
 protein coding gene Chr8:72068165-72083053 (-)
BALB/cJ MGP_BALBcJ_G0033759
 protein coding gene Chr8:70140138-70155040 (-)
C3H/HeJ MGP_C3HHeJ_G0033468
 protein coding gene Chr8:72705009-72719930 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034279
 protein coding gene Chr8:75727295-75741946 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031220
 protein coding gene Chr8:64518970-64533115 (-)
CAST/EiJ MGP_CASTEiJ_G0032797
 protein coding gene Chr8:72050163-72064896 (-)
CBA/J MGP_CBAJ_G0033447
 protein coding gene Chr8:78435477-78451382 (-)
DBA/2J MGP_DBA2J_G0033601
 protein coding gene Chr8:69743468-69759293 (-)
FVB/NJ MGP_FVBNJ_G0033546
 protein coding gene Chr8:68819809-68836712 (-)
LP/J MGP_LPJ_G0033690
 protein coding gene Chr8:73040817-73056460 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033590
 protein coding gene Chr8:80918687-80933729 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034296
 protein coding gene Chr8:72144989-72162711 (-)
PWK/PhJ MGP_PWKPhJ_G0032503
 protein coding gene Chr8:69006920-69021949 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032341
 protein coding gene Chr8:71077496-71093322 (-)
WSB/EiJ MGP_WSBEiJ_G0032912
 protein coding gene Chr8:72447519-72462417 (-)



Homology
more
  • Human Ortholog
    CHERP, calcium homeostasis endoplasmic reticulum protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHERP, calcium homeostasis endoplasmic reticulum protein
  • Synonyms
    DAN16, SCAF6, SRA1
  • Links
    NCBI Gene ID: 10523
    neXtProt AC: NX_Q8IWX8
    UniProt: Q8IWX8

  • Chr Location
    19p13.11; chr19:16517894-16542437 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal morula morphology and complete embryonic lethality prior to organogenesis. Blastocysts hatch from the zona pellucida but form outgrowths with no defined inner cell mass and few trophectoderm cells after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052488 Ensembl Gene Model | MGI Sequence Detail 14738 C57BL/6J ±  kb
    transcript ENSMUST00000079510 Ensembl | MGI Sequence Detail 3713 Not Applicable  
    polypeptide ENSMUSP00000078469 Ensembl | MGI Sequence Detail 949 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34111, MGI:1917769
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory