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Rfx3 Gene Detail
Summary
  • Symbol
    Rfx3
  • Name
    regulatory factor X, 3 (influences HLA class II expression)
  • Synonyms
    C230093O12Rik, MRFX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106582
    NCBI Gene: 19726
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:27739121-27988566 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 22.36 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106582
 protein coding gene Chr19:27739121-27995287 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025010
 protein coding gene Chr19:26139597-26394937 (-)
A/J MGP_AJ_G0024987
 protein coding gene Chr19:24796444-25047800 (-)
AKR/J MGP_AKRJ_G0024955
 protein coding gene Chr19:25734241-25994422 (-)
BALB/cJ MGP_BALBcJ_G0024986
 protein coding gene Chr19:24837396-25085146 (-)
C3H/HeJ MGP_C3HHeJ_G0024742
 protein coding gene Chr19:25681841-25935345 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025427
 protein coding gene Chr19:26889432-27151010 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022846
 protein coding gene Chr19:24807246-25053289 (-)
CAST/EiJ MGP_CASTEiJ_G0024212
 protein coding gene Chr19:25471498-25741031 (-)
CBA/J MGP_CBAJ_G0024720
 protein coding gene Chr19:28163763-28423512 (-)
DBA/2J MGP_DBA2J_G0024852
 protein coding gene Chr19:24763492-25021014 (-)
FVB/NJ MGP_FVBNJ_G0024814
 protein coding gene Chr19:24617662-24866309 (-)
LP/J MGP_LPJ_G0024937
 protein coding gene Chr19:26139382-26391553 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024841
 protein coding gene Chr19:28055780-28374819 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025482
 protein coding gene Chr19:25728718-25986146 (-)
PWK/PhJ MGP_PWKPhJ_G0023960
 protein coding gene Chr19:24408748-24669244 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023764
 protein coding gene Chr19:24980722-25234676 (-)
WSB/EiJ MGP_WSBEiJ_G0024279
 protein coding gene Chr19:25753602-26023062 (-)



Homology
more
  • Human Ortholog
    RFX3, regulatory factor X3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFX3, regulatory factor X3
  • Links
    NCBI Gene ID: 5991
    neXtProt AC: NX_P48380
    UniProt: P48380

  • Chr Location
    9p24.2; chr9:3218297-3526004 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rfx3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    4 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic and perinatal lethality, impaired development of cilia on the embryonic node, abnormal left-right patterning, meso- and dextrocardia, and situs inversus in surviving adults.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    64
  • cDNA Data
    42
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040929 Ensembl Gene Model | MGI Sequence Detail 249446 C57BL/6J ±  kb
    transcript ENSMUST00000174850 Ensembl | MGI Sequence Detail 2743 Not Applicable  
    polypeptide ENSMUSP00000133461 Ensembl | MGI Sequence Detail 749 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 44
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-35038, MGI:2444250
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:32459 Reith W, et al., RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol. 1994 Feb;14(2):1230-44
    • Latest
      J:321365 Knoedler JR, et al., A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2022 Feb 17;185(4):654-671.e22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory