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Omg Gene Detail
Summary
  • Symbol
    Omg
  • Name
    oligodendrocyte myelin glycoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:106586
    NCBI Gene: 18377
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:79391808-79394908 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 46.79 cM, cytoband B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106586
 protein coding gene Chr11:79391808-79394910 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018797
 protein coding gene Chr11:80605812-80608914 (-)
A/J MGP_AJ_G0018764
 protein coding gene Chr11:77505967-77509057 (-)
AKR/J MGP_AKRJ_G0018734
 protein coding gene Chr11:79831584-79834904 (-)
BALB/cJ MGP_BALBcJ_G0018737
 protein coding gene Chr11:77913364-77917741 (-)
C3H/HeJ MGP_C3HHeJ_G0018551
 protein coding gene Chr11:79886268-79892973 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019189
 protein coding gene Chr11:83086948-83090050 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016823
 protein coding gene Chr11:74452640-74455782 (-)
CAST/EiJ MGP_CASTEiJ_G0018106
 protein coding gene Chr11:80360404-80363497 (-)
CBA/J MGP_CBAJ_G0018522
 protein coding gene Chr11:86705205-86708511 (-)
DBA/2J MGP_DBA2J_G0018630
 protein coding gene Chr11:77057074-77060176 (-)
FVB/NJ MGP_FVBNJ_G0018619
 protein coding gene Chr11:76655177-76658269 (-)
LP/J MGP_LPJ_G0018700
 protein coding gene Chr11:81115627-81118715 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018646
 protein coding gene Chr11:87002971-87006071 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019229
 protein coding gene Chr11:80093992-80097094 (-)
PWK/PhJ MGP_PWKPhJ_G0017876
 protein coding gene Chr11:77873840-77876921 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017667
 protein coding gene Chr11:79699838-79702911 (-)
WSB/EiJ MGP_WSBEiJ_G0018158
 protein coding gene Chr11:79919345-79922453 (-)



Homology
more
  • Human Ortholog
    OMG, oligodendrocyte myelin glycoprotein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OMG, oligodendrocyte myelin glycoprotein
  • Synonyms
    OMGP
  • Links
    NCBI Gene ID: 4974
    neXtProt AC: NX_P23515
    UniProt: P23515

  • Chr Location
    17q11.2; chr17:31272013-31297539 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit improved recovery from spinal cord injuries when on a mixed 129S4/SvJae C57BL/6 background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    28
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18377 NCBI Gene Model | MGI Sequence Detail 3101 C57BL/6J ±  kb
transcript NM_019409 RefSeq | MGI Sequence Detail 2226 ZRU/MplStud  
polypeptide Q63912 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011637 oligodendrocyte-myelin glycoprotein
    (term hierarchy)
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR051071 Leucine-rich repeat-containing bacterial E3 ubiquitin ligases
    IPR032675 Leucine-rich repeat domain superfamily
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
  • GlyGen
    Q63912 12 sites, 24 N-linked glycans (8 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 11
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-35042
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:316863 Zhai J, et al., Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord. Elife. 2021 May 4;10:e63050
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory