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Tpgs1 Gene Detail
Summary
  • Symbol
    Tpgs1
  • Name
    tubulin polyglutamylase complex subunit 1
  • Synonyms
    Gm16517, Gtrgeo22
  • Feature Type
    protein coding gene
  • IDs
    MGI:106618
    NCBI Gene: 110012
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79505273-79511961 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106618
 protein coding gene Chr10:79505203-79511961 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017451
 protein coding gene Chr10:80205936-80212639 (+)
A/J MGP_AJ_G0017429
 protein coding gene Chr10:77419407-77426882 (+)
AKR/J MGP_AKRJ_G0017390
 protein coding gene Chr10:79525102-79531816 (+)
BALB/cJ MGP_BALBcJ_G0017391
 protein coding gene Chr10:77648274-77654940 (+)
C3H/HeJ MGP_C3HHeJ_G0017214
 protein coding gene Chr10:79631088-79637808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017845
 protein coding gene Chr10:82978729-82985437 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015533
 protein coding gene Chr10:73647208-73654429 (+)
CAST/EiJ MGP_CASTEiJ_G0016781
 protein coding gene Chr10:79805868-79814945 (+)
CBA/J MGP_CBAJ_G0017186
 protein coding gene Chr10:86205530-86212257 (+)
DBA/2J MGP_DBA2J_G0017292
 protein coding gene Chr10:76637805-76644529 (+)
FVB/NJ MGP_FVBNJ_G0017286
 protein coding gene Chr10:75798180-75805392 (+)
LP/J MGP_LPJ_G0017363
 protein coding gene Chr10:80685719-80694003 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017312
 protein coding gene Chr10:88183309-88190034 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017886
 protein coding gene Chr10:79504466-79511175 (+)
PWK/PhJ MGP_PWKPhJ_G0016562
 protein coding gene Chr10:76495173-76501807 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016351
 protein coding gene Chr10:78479668-78486347 (+)
WSB/EiJ MGP_WSBEiJ_G0016841
 protein coding gene Chr10:79532433-79539151 (+)



Homology
more
  • Human Ortholog
    TPGS1, tubulin polyglutamylase complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPGS1, tubulin polyglutamylase complex subunit 1
  • Synonyms
    C19orf20, GTRGEO22, PGs1
  • Links
    NCBI Gene ID: 91978
    neXtProt AC: NX_Q6ZTW0
    UniProt: Q6ZTW0

  • Chr Location
    19p13.3; chr19:507497-519654 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a gene trapped allele are sterile due to abnormal development of the spermatid flagellum. Adult males display a striking deficit in intermale aggression and reduced body fat, not due to an altered resting metabolic rate or hypophagia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110012 NCBI Gene Model | MGI Sequence Detail 6689 C57BL/6J ±  kb
    transcript NM_148934 RefSeq | MGI Sequence Detail 1073 ZRU/MplStud  
    polypeptide Q99MS8 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031177 tubulin polyglutamylase complex subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR039235 Tubulin polyglutamylase complex subunit 1
      IPR047502 Tubulin polyglutamylase complex subunit 1, dimerization/docking domain
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 38
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35075
    References
    more
    • Summaries
      All 41
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256244 Valnegri P, et al., RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Nat Commun. 2017 Nov 2;8(1):1271
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory