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Eif4a2 Gene Detail
Summary
  • Symbol
    Eif4a2
  • Name
    eukaryotic translation initiation factor 4A2
  • Synonyms
    4833432N07Rik, BM-010, Ddx2b, Eif4
  • Feature Type
    protein coding gene
  • IDs
    MGI:106906
    NCBI Gene: 13682
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22926194-22932886 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106906
 protein coding gene Chr16:22924846-22932886 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022678
 protein coding gene Chr16:20668367-20675800 (+)
A/J MGP_AJ_G0022640
 protein coding gene Chr16:19675600-19681710 (+)
AKR/J MGP_AKRJ_G0022614
 protein coding gene Chr16:20519105-20524854 (+)
BALB/cJ MGP_BALBcJ_G0022645
 protein coding gene Chr16:19882618-19888852 (+)
C3H/HeJ MGP_C3HHeJ_G0022409
 protein coding gene Chr16:20637961-20645054 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023094
 protein coding gene Chr16:21154129-21175042 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020612
 protein coding gene Chr16:20311695-20317694 (+)
CAST/EiJ MGP_CASTEiJ_G0021938
 protein coding gene Chr16:20611365-20617747 (+)
CBA/J MGP_CBAJ_G0022380
 protein coding gene Chr16:22022581-22028495 (+)
DBA/2J MGP_DBA2J_G0022512
 protein coding gene Chr16:19636149-19642347 (+)
FVB/NJ MGP_FVBNJ_G0022488
 protein coding gene Chr16:19630346-19636833 (+)
LP/J MGP_LPJ_G0022580
 protein coding gene Chr16:20460154-20469577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022507
 protein coding gene Chr16:21561452-21567835 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023106
 protein coding gene Chr16:20466852-20475533 (+)
PWK/PhJ MGP_PWKPhJ_G0021677
 protein coding gene Chr16:19904872-19912427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021508
 protein coding gene Chr16:20204448-20210816 (+)
WSB/EiJ MGP_WSBEiJ_G0021982
 protein coding gene Chr16:20413605-20421010 (+)



Homology
more
  • Human Ortholog
    EIF4A2, eukaryotic translation initiation factor 4A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4A2, eukaryotic translation initiation factor 4A2
  • Synonyms
    BM-010, DDX2B, EIF4A, eIF-4A-II, eIF4A-II, EIF4F, NEDHSS
  • Links
    NCBI Gene ID: 1974
    neXtProt AC: NX_Q14240
    UniProt: Q14240

  • Chr Location
    3q27.3; chr3:186783205-186789897 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF4A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    12
  • cDNA Data
    15
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022884 Ensembl Gene Model | MGI Sequence Detail 6693 C57BL/6J ±  kb
    transcript ENSMUST00000023599 Ensembl | MGI Sequence Detail 2208 Not Applicable  
    polypeptide ENSMUSP00000023599 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006987 eukaryotic initiation factor 4A-II
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR044728 ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain
      IPR011545 DEAD/DEAH box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    • GlyGen
      P10630 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 15
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35367, MGD-MRK-9336, MGI:2442677
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:9356 Nielsen PJ, et al., The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J. 1988 Jul;7(7):2097-105
    • Latest
      J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory