About   Help   FAQ
Tead4 Gene Detail
Summary
  • Symbol
    Tead4
  • Name
    TEA domain family member 4
  • Synonyms
    Etfr2, ETFR-2a, Rtef1, Tcf13r1, TEAD-4, Tef3, TEF-3, Tefr, Tefr1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:106907
    NCBI Gene: 21679
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128204106-128277776 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 62.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2214 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106907
 protein coding gene Chr6:128201251-128277786 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031319
 protein coding gene Chr6:131823457-131900009 (-)
A/J MGP_AJ_G0031290
 protein coding gene Chr6:126770740-126844908 (-)
AKR/J MGP_AKRJ_G0031218
 protein coding gene Chr6:130184951-130258591 (-)
BALB/cJ MGP_BALBcJ_G0031297
 protein coding gene Chr6:126339664-126412410 (-)
C3H/HeJ MGP_C3HHeJ_G0031021
 protein coding gene Chr6:130321731-130397515 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031756
 protein coding gene Chr6:135251286-135331970 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028902
 protein coding gene Chr6:123972862-124046091 (-)
CAST/EiJ MGP_CASTEiJ_G0030403
 protein coding gene Chr6:130604223-130681185 (-)
CBA/J MGP_CBAJ_G0030982
 protein coding gene Chr6:140467284-140542757 (-)
DBA/2J MGP_DBA2J_G0031138
 protein coding gene Chr6:125663615-125736240 (-)
FVB/NJ MGP_FVBNJ_G0031088
 protein coding gene Chr6:124586342-124659771 (-)
LP/J MGP_LPJ_G0031218
 protein coding gene Chr6:131945055-132019136 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031126
 protein coding gene Chr6:144315644-144393566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031789
 protein coding gene Chr6:130189450-130267960 (-)
PWK/PhJ MGP_PWKPhJ_G0030118
 protein coding gene Chr6:123959404-124038384 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029946
 protein coding gene Chr6:128295642-128378929 (-)
WSB/EiJ MGP_WSBEiJ_G0030487
 protein coding gene Chr6:130570774-130658942 (-)



Homology
more
  • Human Ortholog
    TEAD4, TEA domain transcription factor 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEAD4, TEA domain transcription factor 4
  • Synonyms
    EFTR-2, hRTEF-1B, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1
  • Links
    NCBI Gene ID: 7004
    neXtProt AC: NX_Q15561
    UniProt: Q15561

  • Chr Location
    12p13.33; chr12:2959330-3040676 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to somitogenesis, lack trophoblast stem cells and develop abnormally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1052
  • Tissues
    224
  • cDNA Data
    45
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21679 NCBI Gene Model | MGI Sequence Detail 73671 C57BL/6J ±  kb
    transcript NM_011567 RefSeq | MGI Sequence Detail 3076 Not Specified  
    polypeptide Q62296 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 46
      Primer pair 12
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35368
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 36
      Gene Ontology 13
      Phenotypes 19
    • Earliest
      J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
    • Latest
      J:352881 Zhu M, et al., Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification. Nat Struct Mol Biol. 2024 Jun;31(6):964-976
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory