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Mttp Gene Detail
Summary
  • Symbol
    Mttp
  • Name
    microsomal triglyceride transfer protein
  • Synonyms
    1810043K16Rik, MTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:106926
    NCBI Gene: 17777
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:137795616-137849179 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.06 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1946 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106926
 protein coding gene Chr3:137795615-137850729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027924
 protein coding gene Chr3:141133722-141193942 (-)
A/J MGP_AJ_G0027881
 protein coding gene Chr3:136139606-136193512 (-)
AKR/J MGP_AKRJ_G0027847
 protein coding gene Chr3:139762305-139815596 (-)
BALB/cJ MGP_BALBcJ_G0027893
 protein coding gene Chr3:135950409-136002086 (-)
C3H/HeJ MGP_C3HHeJ_G0027623
 protein coding gene Chr3:140088799-140143257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028337
 protein coding gene Chr3:145992836-146049714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025675
 protein coding gene Chr3:131244799-131613571 (-)
CAST/EiJ MGP_CASTEiJ_G0027079
 protein coding gene Chr3:139840472-139915995 (-)
CBA/J MGP_CBAJ_G0027600
 protein coding gene Chr3:150962414-151020257 (-)
DBA/2J MGP_DBA2J_G0027739
 protein coding gene Chr3:135261714-135314873 (-)
FVB/NJ MGP_FVBNJ_G0027706
 protein coding gene Chr3:132723697-132777371 (-)
LP/J MGP_LPJ_G0027849
 protein coding gene Chr3:142534257-142588634 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027738
 protein coding gene Chr3:159060540-159116126 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028395
 protein coding gene Chr3:139300136-139359551 (-)
PWK/PhJ MGP_PWKPhJ_G0026803
 protein coding gene Chr3:135002340-135069297 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026630
 protein coding gene Chr3:137393268-137453298 (-)
WSB/EiJ MGP_WSBEiJ_G0027158
 protein coding gene Chr3:140132245-140189067 (-)



Homology
more
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTTP, microsomal triglyceride transfer protein
  • Synonyms
    ABL, MTP
  • Links
    NCBI Gene ID: 4547
    neXtProt AC: NX_P55157
    UniProt: P55157

  • Chr Location
    4q23; chr4:99564081-99623997 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human MTTP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most embryos homozygous for a reporter allele die at midgestation displaying delayed growth, neurodevelopmental anomalies, impaired erythropoiesis, deficient yolk sac lipoprotein production, hemorrhage and necrosis. Heterozygous mutant mice display altered plasma lipid and lipoprotein profiles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    50
  • cDNA Data
    52
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17777 NCBI Gene Model | MGI Sequence Detail 53564 C57BL/6J ±  kb
    transcript NM_001355052 RefSeq | MGI Sequence Detail 4504 ZRU/MplStud  
    polypeptide O08601 UniProt | EBI | MGI Sequence Detail 894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003392 microsomal triglyceride transfer protein large subunit
      (term hierarchy)
    • InterPro Domains
      IPR015819 Lipid transport protein, beta-sheet shell
      IPR011030 Lipovitellin-phosvitin complex, superhelical domain
      IPR039988 Microsomal triglyceride transfer protein large subunit
      IPR045811 MTP large subunit, lipid-binding domain
      IPR015816 Vitellinogen, beta-sheet N-terminal
      IPR001747 Vitellogenin, N-terminal
    • GlyGen
      O08601 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 53
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35387, MGI:1917046
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 16
      Phenotypes 61
    • Earliest
      J:42428 Knecht TP, et al., The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis. Adv Genet. 1995;32:141-98
    • Latest
      J:345662 Chen Z, et al., Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion. Mol Metab. 2024 Feb;80:101874
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory