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Shroom2 Gene Detail
Summary
  • Symbol
    Shroom2
  • Name
    shroom family member 2
  • Synonyms
    Apxl, Shrm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107194
    NCBI Gene: 110380
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:151392505-151552461 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband F2-F3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3053 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107194
 protein coding gene ChrX:151392505-151553784 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036188
 protein coding gene ChrX:150404009-150576684 (-)
A/J MGP_AJ_G0036164
 protein coding gene ChrX:149587101-149760519 (-)
AKR/J MGP_AKRJ_G0036090
 protein coding gene ChrX:154401296-154568641 (-)
BALB/cJ MGP_BALBcJ_G0036155
 protein coding gene ChrX:147764233-147926541 (-)
C3H/HeJ MGP_C3HHeJ_G0035863
 protein coding gene ChrX:150615777-150784141 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036680
 protein coding gene ChrX:154687080-154888187 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033504
 protein coding gene ChrX:141268615-141439472 (-)
CAST/EiJ MGP_CASTEiJ_G0035154
 protein coding gene ChrX:129991338-130158116 (-)
CBA/J MGP_CBAJ_G0035840
 protein coding gene ChrX:159231676-159401024 (-)
DBA/2J MGP_DBA2J_G0035998
 protein coding gene ChrX:148606098-148779449 (-)
FVB/NJ MGP_FVBNJ_G0035932
 protein coding gene ChrX:147762620-147938139 (-)
LP/J MGP_LPJ_G0036089
 protein coding gene ChrX:151475063-151629233 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035968
 protein coding gene ChrX:167425528-167607367 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036715
 protein coding gene ChrX:149921386-150090358 (-)
PWK/PhJ MGP_PWKPhJ_G0034848
 protein coding gene ChrX:126907880-127083305 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034674
 protein coding gene ChrX:130423907-130590621 (-)
WSB/EiJ MGP_WSBEiJ_G0035289
 protein coding gene ChrX:147965369-148129580 (-)



Homology
more
  • Human Ortholog
    SHROOM2, shroom family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHROOM2, shroom family member 2
  • Synonyms
    APXL, HSAPXL
  • Links
    NCBI Gene ID: 357
    neXtProt AC: NX_Q13796
    UniProt: Q13796

  • Chr Location
    Xp22.2; chrX:9786429-9949443 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    31
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045180 Ensembl Gene Model | MGI Sequence Detail 159957 C57BL/6J ±  kb
    transcript ENSMUST00000101141 Ensembl | MGI Sequence Detail 7494 Not Applicable  
    polypeptide ENSMUSP00000098701 Ensembl | MGI Sequence Detail 1487 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35655, MGI:2443591
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:33821 Dinulos MB, et al., A new region of conservation is defined between human and mouse X chromosomes. Genomics. 1996 Jul 1;35(1):244-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory