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Zic4 Gene Detail
Summary
  • Symbol
    Zic4
  • Name
    zinc finger protein of the cerebellum 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107201
    NCBI Gene: 22774
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:91247636-91271404 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 48.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107201
 protein coding gene Chr9:91244466-91271404 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035124
 protein coding gene Chr9:92377684-92405178 (+)
A/J MGP_AJ_G0035105
 protein coding gene Chr9:89167288-89193834 (+)
AKR/J MGP_AKRJ_G0035037
 protein coding gene Chr9:91235623-91263444 (+)
BALB/cJ MGP_BALBcJ_G0035098
 protein coding gene Chr9:88793021-88819361 (+)
C3H/HeJ MGP_C3HHeJ_G0034808
 protein coding gene Chr9:91712642-91740107 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035618
 protein coding gene Chr9:94943120-94976981 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032521
 protein coding gene Chr9:87238782-87265488 (+)
CAST/EiJ MGP_CASTEiJ_G0034120
 protein coding gene Chr9:91466740-91495612 (+)
CBA/J MGP_CBAJ_G0034776
 protein coding gene Chr9:98208794-98247657 (+)
DBA/2J MGP_DBA2J_G0034938
 protein coding gene Chr9:88690855-88717464 (+)
FVB/NJ MGP_FVBNJ_G0034886
 protein coding gene Chr9:87672210-87698663 (+)
LP/J MGP_LPJ_G0035017
 protein coding gene Chr9:92592770-92619700 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034925
 protein coding gene Chr9:100007322-100033621 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035638
 protein coding gene Chr9:91493227-91521406 (+)
PWK/PhJ MGP_PWKPhJ_G0033827
 protein coding gene Chr9:88853299-88884081 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033660
 protein coding gene Chr9:91504481-91540316 (+)
WSB/EiJ MGP_WSBEiJ_G0034240
 protein coding gene Chr9:91387186-91415448 (+)



Homology
more
  • Human Ortholog
    ZIC4, Zic family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZIC4, Zic family member 4
  • Links
    NCBI Gene ID: 84107
    neXtProt AC: NX_Q8N9L1
    UniProt: Q8N9L1

  • Chr Location
    3q24; chr3:147386046-147406809 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zic4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit posterior cerebellar hypoplasia and a mild defect in anterior cerebellar foliation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    148
  • cDNA Data
    16
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22774 NCBI Gene Model | MGI Sequence Detail 23769 C57BL/6J ±  kb
    transcript NM_001421110 RefSeq | MGI Sequence Detail 5616 ZRU/MplStud  
    polypeptide Q61467 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 4
      cDNA 17
      Primer pair 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35662
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:33727 Aruga J, et al., Identification and characterization of Zic4, a new member of the mouse Zic gene family. Gene. 1996 Jun 26;172(2):291-4
    • Latest
      J:347410 Chen Z, et al., Increased enhancer-promoter interactions during developmental enhancer activation in mammals. Nat Genet. 2024 Apr;56(4):675-685
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory