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Stxbp2 Gene Detail
Summary
  • Symbol
    Stxbp2
  • Name
    syntaxin binding protein 2
  • Synonyms
    C79054, Munc-18-2, Munc-18b, Munc18b, muSec1, Sxtp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107370
    NCBI Gene: 20911
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3680955-3693644 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    396 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107370
 protein coding gene Chr8:3680955-3693998 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033312
 protein coding gene Chr8:575766-589308 (+)
A/J MGP_AJ_G0033295
 protein coding gene Chr8:547313-560008 (+)
AKR/J MGP_AKRJ_G0033226
 protein coding gene Chr8:575053-589912 (+)
BALB/cJ MGP_BALBcJ_G0033295
 protein coding gene Chr8:572893-585768 (+)
C3H/HeJ MGP_C3HHeJ_G0033009
 protein coding gene Chr8:588199-602000 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033805
 protein coding gene Chr8:618331-634622 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030778
 protein coding gene Chr8:498049-510368 (+)
CAST/EiJ MGP_CASTEiJ_G0032332
 protein coding gene Chr8:582499-594988 (+)
CBA/J MGP_CBAJ_G0032982
 protein coding gene Chr8:632711-648213 (+)
DBA/2J MGP_DBA2J_G0033136
 protein coding gene Chr8:517794-530593 (+)
FVB/NJ MGP_FVBNJ_G0033083
 protein coding gene Chr8:566611-579712 (+)
LP/J MGP_LPJ_G0033228
 protein coding gene Chr8:560341-573592 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033118
 protein coding gene Chr8:612773-628282 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033823
 protein coding gene Chr8:569102-581561 (+)
PWK/PhJ MGP_PWKPhJ_G0032042
 protein coding gene Chr8:545394-558530 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031886
 protein coding gene Chr8:558510-570964 (+)
WSB/EiJ MGP_WSBEiJ_G0032445
 protein coding gene Chr8:564071-578133 (+)



Homology
more
  • Human Ortholog
    STXBP2, syntaxin binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STXBP2, syntaxin binding protein 2
  • Synonyms
    FHL5, Hunc18b, MUNC18-2, pp10122, UNC18-2, unc-18B, UNC18B
  • Links
    NCBI Gene ID: 6813
    neXtProt AC: NX_Q15833
    UniProt: Q15833

  • Chr Location
    19p13.2; chr19:7629793-7647873 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STXBP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete preweaning lethality. Mice heterozygous for this allele exhibit decreased stimulated mucin secretion, release of histones in stimulated mast cells and decreased susceptibility to type I hypersensitivity reaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1172
  • Tissues
    94
  • cDNA Data
    104
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004626 Ensembl Gene Model | MGI Sequence Detail 12690 C57BL/6J ±  kb
    transcript ENSMUST00000004745 Ensembl | MGI Sequence Detail 1847 Not Applicable  
    polypeptide ENSMUSP00000004745 Ensembl | MGI Sequence Detail 594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 105
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33866, MGD-MRK-35837, MGI:2142858
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 7
    • Earliest
      J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
    • Latest
      J:335621 Yang M, et al., STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion. Immunity. 2023 May 9;56(5):1013-1026.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory