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Pctp Gene Detail
Summary
  • Symbol
    Pctp
  • Name
    phosphatidylcholine transfer protein
  • Synonyms
    PC-TP, StarD2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107375
    NCBI Gene: 18559
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:89873491-89893720 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 54.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    887 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107375
 protein coding gene Chr11:89873370-89893720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018935
 protein coding gene Chr11:91779459-91801709 (-)
A/J MGP_AJ_G0018903
 protein coding gene Chr11:88188259-88209710 (-)
AKR/J MGP_AKRJ_G0018873
 protein coding gene Chr11:90903662-90927173 (-)
BALB/cJ MGP_BALBcJ_G0018876
 protein coding gene Chr11:88641270-88663552 (-)
C3H/HeJ MGP_C3HHeJ_G0018690
 protein coding gene Chr11:90923328-90945550 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019328
 protein coding gene Chr11:94663687-94683951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016959
 protein coding gene Chr11:85233424-85253831 (-)
CAST/EiJ MGP_CASTEiJ_G0018245
 protein coding gene Chr11:91668445-91689606 (-)
CBA/J MGP_CBAJ_G0018661
 protein coding gene Chr11:98609084-98631582 (-)
DBA/2J MGP_DBA2J_G0018769
 protein coding gene Chr11:87742291-87763706 (-)
FVB/NJ MGP_FVBNJ_G0018758
 protein coding gene Chr11:87253804-87280748 (-)
LP/J MGP_LPJ_G0018839
 protein coding gene Chr11:92286638-92309963 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018785
 protein coding gene Chr11:98479126-98502374 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019368
 protein coding gene Chr11:91140168-91171175 (-)
PWK/PhJ MGP_PWKPhJ_G0018015
 protein coding gene Chr11:88641525-88661781 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017805
 protein coding gene Chr11:90718898-90739057 (-)
WSB/EiJ MGP_WSBEiJ_G0018294
 protein coding gene Chr11:91015835-91037334 (-)



Homology
more
  • Human Ortholog
    PCTP, phosphatidylcholine transfer protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCTP, phosphatidylcholine transfer protein
  • Synonyms
    PC-TP, STARD2
  • Links
    NCBI Gene ID: 58488
    neXtProt AC: NX_Q9UKL6
    UniProt: Q9UKL6

  • Chr Location
    17q22; chr17:55751051-55852715 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired biliary lipid secretion in response to a lithogenic diet, and show altered adaptive responses of macrophages to cholesterol loading. Mice heterozygous for a spontaneous allele show lack of phosphatidylcholine transfer protein activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    42
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020553 Ensembl Gene Model | MGI Sequence Detail 20230 C57BL/6J ±  kb
    transcript ENSMUST00000020864 Ensembl | MGI Sequence Detail 2723 Not Applicable  
    polypeptide ENSMUSP00000020864 Ensembl | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35842
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:258820 Ersoy BA, et al., Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress. J Clin Invest. 2018 Jan 2;128(1):141-156
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory