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Plcd3 Gene Detail
Summary
  • Symbol
    Plcd3
  • Name
    phospholipase C, delta 3
  • Synonyms
    2610205J15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107451
    NCBI Gene: 72469
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102961130-102992484 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 66.71 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    704 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107451
 protein coding gene Chr11:102960062-102992484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019254
 protein coding gene Chr11:106115639-106137944 (-)
A/J MGP_AJ_G0019222
 protein coding gene Chr11:101620421-101644199 (-)
AKR/J MGP_AKRJ_G0019191
 protein coding gene Chr11:104755305-104778783 (-)
BALB/cJ MGP_BALBcJ_G0019196
 protein coding gene Chr11:102093143-102115476 (-)
C3H/HeJ MGP_C3HHeJ_G0019005
 protein coding gene Chr11:104980910-105004279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019645
 protein coding gene Chr11:109418005-109448304 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017271
 protein coding gene Chr11:99037450-99060523 (-)
CAST/EiJ MGP_CASTEiJ_G0018559
 protein coding gene Chr11:105992205-106014062 (-)
CBA/J MGP_CBAJ_G0018974
 protein coding gene Chr11:113966537-113996594 (-)
DBA/2J MGP_DBA2J_G0019086
 protein coding gene Chr11:101133092-101155420 (-)
FVB/NJ MGP_FVBNJ_G0019076
 protein coding gene Chr11:100674940-100697674 (-)
LP/J MGP_LPJ_G0019155
 protein coding gene Chr11:106634521-106658424 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019107
 protein coding gene Chr11:113363429-113385296 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019683
 protein coding gene Chr11:105137955-105163893 (-)
PWK/PhJ MGP_PWKPhJ_G0018322
 protein coding gene Chr11:102201827-102224039 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018114
 protein coding gene Chr11:104895886-104919195 (-)
WSB/EiJ MGP_WSBEiJ_G0018608
 protein coding gene Chr11:105138248-105161707 (-)



Homology
more
  • Human Ortholog
    PLCD3, phospholipase C delta 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCD3, phospholipase C delta 3
  • Synonyms
    PLC-delta-3
  • Links
    NCBI Gene ID: 113026
    neXtProt AC: NX_Q8N3E9
    UniProt: Q8N3E9

  • Chr Location
    17q21.31; chr17:45108959-45133354 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    105
  • cDNA Data
    23
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020937 Ensembl Gene Model | MGI Sequence Detail 31355 C57BL/6J ±  kb
transcript ENSMUST00000103077 Ensembl | MGI Sequence Detail 3023 Not Applicable  
polypeptide ENSMUSP00000099366 Ensembl | MGI Sequence Detail 785 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012833 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
    (term hierarchy)
  • EC
    3.1.4.11
  • InterPro Domains
    IPR039504 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain
    IPR000008 C2 domain
    IPR035892 C2 domain superfamily
    IPR011992 EF-hand domain pair
    IPR011993 PH-like domain superfamily
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR001192 Phosphoinositide phospholipase C family
    IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    IPR001849 Pleckstrin homology domain
  • GlyGen
    Q8K2J0 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 28
    cDNA 25
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-35922, MGI:1919719
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
  • Latest
    J:316051 Nakamura Y, et al., Simultaneous loss of phospholipase Cdelta1 and phospholipase Cdelta3 causes cardiomyocyte apoptosis and cardiomyopathy. Cell Death Dis. 2014 May 8;5:e1215
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory