About   Help   FAQ
Plcb4 Gene Detail
Summary
  • Symbol
    Plcb4
  • Name
    phospholipase C, beta 4
  • Synonyms
    A930039J07Rik, C230058B11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107464
    NCBI Gene: 18798
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:135500931-135856513 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 66.64 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9847 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107464
 protein coding gene Chr2:135500523-135856522 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026555
 protein coding gene Chr2:139390242-139773302 (+)
A/J MGP_AJ_G0026519
 protein coding gene Chr2:133717242-134092279 (+)
AKR/J MGP_AKRJ_G0026493
 protein coding gene Chr2:137579241-137946080 (+)
BALB/cJ MGP_BALBcJ_G0026531
 protein coding gene Chr2:134123203-134483517 (+)
C3H/HeJ MGP_C3HHeJ_G0026274
 protein coding gene Chr2:138036016-138400801 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026976
 protein coding gene Chr2:143603472-143982249 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024353
 protein coding gene Chr2:128296780-128649520 (+)
CAST/EiJ MGP_CASTEiJ_G0025735
 protein coding gene Chr2:138364120-138745794 (+)
CBA/J MGP_CBAJ_G0026254
 protein coding gene Chr2:148957977-149351044 (+)
DBA/2J MGP_DBA2J_G0026388
 protein coding gene Chr2:133102713-133470744 (+)
FVB/NJ MGP_FVBNJ_G0026352
 protein coding gene Chr2:131703068-132061649 (+)
LP/J MGP_LPJ_G0026492
 protein coding gene Chr2:139571477-139945686 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026372
 protein coding gene Chr2:152781187-153154503 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027031
 protein coding gene Chr2:137582043-137953944 (+)
PWK/PhJ MGP_PWKPhJ_G0025471
 protein coding gene Chr2:132701984-133071501 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025273
 protein coding gene Chr2:136685764-137052976 (+)
WSB/EiJ MGP_WSBEiJ_G0025809
 protein coding gene Chr2:138507452-138882328 (+)



Homology
more
  • Human Ortholog
    PLCB4, phospholipase C beta 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCB4, phospholipase C beta 4
  • Synonyms
    ARCND2, ARCND2A, ARCND2B, PI-PLC
  • Links
    NCBI Gene ID: 5332
    neXtProt AC: NX_Q15147
    UniProt: Q15147

  • Chr Location
    20p12.3-p12.2; chr20:9067825-9504593 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations may exhibit ataxia, impaired elimination of excess climbing fiber synapses in the developing cerebellum, abnormal cerebellar foliation, reduced visual processing ability and loss of circadian rhythm in constant darkness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1033
  • Tissues
    179
  • cDNA Data
    66
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039943 Ensembl Gene Model | MGI Sequence Detail 355583 C57BL/6J ±  kb
    transcript ENSMUST00000110109 Ensembl | MGI Sequence Detail 5217 Not Applicable  
    polypeptide ENSMUSP00000105736 Ensembl | MGI Sequence Detail 1175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • PDB
      6IRD
    • EC
      3.1.4.11
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR014815 Phospholipase C-beta, C-terminal domain
      IPR042531 Phospholipase C-beta, C-terminal domain superfamily
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR037862 PLC-beta, PH domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    • GlyGen
      Q91UZ1 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 68
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35936, MGI:1925078, MGI:2139106, MGI:2443533
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 5
      Phenotypes 67
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory