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Stim1 Gene Detail
Summary
  • Symbol
    Stim1
  • Name
    stromal interaction molecule 1
  • Synonyms
    SIM
  • Feature Type
    protein coding gene
  • IDs
    MGI:107476
    NCBI Gene: 20866
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101917013-102086526 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3538 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107476
 protein coding gene Chr7:101909279-102086526 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032607
 protein coding gene Chr7:105313999-105492464 (+)
A/J MGP_AJ_G0032583
 protein coding gene Chr7:102623018-102794703 (+)
AKR/J MGP_AKRJ_G0032519
 protein coding gene Chr7:105073593-105254399 (+)
BALB/cJ MGP_BALBcJ_G0032594
 protein coding gene Chr7:102326694-102496130 (+)
C3H/HeJ MGP_C3HHeJ_G0032308
 protein coding gene Chr7:105473945-105650975 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033091
 protein coding gene Chr7:109271227-109451833 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030085
 protein coding gene Chr7:104975585-105142268 (+)
CAST/EiJ MGP_CASTEiJ_G0031634
 protein coding gene Chr7:97020341-97203060 (+)
CBA/J MGP_CBAJ_G0032274
 protein coding gene Chr7:113100807-113285366 (+)
DBA/2J MGP_DBA2J_G0032426
 protein coding gene Chr7:100949325-101118220 (+)
FVB/NJ MGP_FVBNJ_G0032382
 protein coding gene Chr7:100734148-100901582 (+)
LP/J MGP_LPJ_G0032515
 protein coding gene Chr7:106622778-106799298 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032416
 protein coding gene Chr7:114369270-114553319 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033113
 protein coding gene Chr7:104349998-104541334 (+)
PWK/PhJ MGP_PWKPhJ_G0031352
 protein coding gene Chr7:94069552-94241449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031196
 protein coding gene Chr7:91649949-91830485 (+)
WSB/EiJ MGP_WSBEiJ_G0031751
 protein coding gene Chr7:105041341-105215030 (+)



Homology
more
  • Human Ortholog
    STIM1, stromal interaction molecule 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STIM1, stromal interaction molecule 1
  • Synonyms
    D11S4896E, GOK, IMD10, STRMK, TAM, TAM1
  • Links
    NCBI Gene ID: 6786
    neXtProt AC: NX_Q13586
    UniProt: Q13586

  • Chr Location
    11p15.4; chr11:3854527-4093210 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Stim1 mouse models; 6 with human STIM1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    129 phenotypes from 10 alleles in 11 genetic backgrounds
    33 phenotypes from multigenic genotypes
    2 images
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit perinatal and postnatal lethality, with all mice dying by 2 weeks of age, and severe growth retardation. Heterozygosity for the p.R304W mutation reduces embryonic survival and adult longevity, affects muscle morphology and physiology, bone morphology, liver physiology, hematopoiesis, and immune cell development. It leads to reduced body size and weight, muscle weakness, bone weakness, bleeding disorder, skin abnormalities, and altered liver and blood chemistry.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    927
  • Tissues
    60
  • cDNA Data
    81
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030987 Ensembl Gene Model | MGI Sequence Detail 169514 C57BL/6J ±  kb
    transcript ENSMUST00000209255 Ensembl | MGI Sequence Detail 4362 Not Applicable  
    polypeptide ENSMUSP00000147443 Ensembl | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015736 stromal interaction molecule 1
      (term hierarchy)
    • InterPro Domains
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR037608 Stromal interaction molecule
      IPR037609 Stromal interaction molecule 1, SAM domain
      IPR032393 Stromal interaction molecule, Orai1-activating region
    • GlyGen
      P70302 8 sites, 7 N-linked glycans (3 sites), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 1
      cDNA 83
      Primer pair 5
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36043, MGD-MRK-37442, MGI:108400
    References
    more
    • Summaries
      All 204
      Developmental Gene Expression 11
      Diseases 3
      Gene Ontology 19
      Phenotypes 128
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:351070 Fresquez AM, et al., STIM1-dependent store-operated calcium entry mediates sex differences in macrophage chemotaxis and monocyte recruitment. J Biol Chem. 2024 May 28;300(7):107422
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory