About   Help   FAQ
Stil Gene Detail
Summary
  • Symbol
    Stil
  • Name
    Scl/Tal1 interrupting locus
  • Synonyms
    Sil
  • Feature Type
    protein coding gene
  • IDs
    MGI:107477
    NCBI Gene: 20460
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:114857356-114900393 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 52.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1289 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107477
 protein coding gene Chr4:114857287-114900404 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028593
 protein coding gene Chr4:115766205-115812201 (+)
A/J MGP_AJ_G0028555
 protein coding gene Chr4:111353416-111401576 (+)
AKR/J MGP_AKRJ_G0028503
 protein coding gene Chr4:113652623-113698069 (+)
BALB/cJ MGP_BALBcJ_G0028575
 protein coding gene Chr4:111986050-112029621 (+)
C3H/HeJ MGP_C3HHeJ_G0028289
 protein coding gene Chr4:115273808-115317103 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029019
 protein coding gene Chr4:120240996-120289017 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026303
 protein coding gene Chr4:105443340-105486479 (+)
CAST/EiJ MGP_CASTEiJ_G0027726
 protein coding gene Chr4:112688484-112734949 (+)
CBA/J MGP_CBAJ_G0028257
 protein coding gene Chr4:123363328-123409430 (+)
DBA/2J MGP_DBA2J_G0028406
 protein coding gene Chr4:111990394-112034081 (+)
FVB/NJ MGP_FVBNJ_G0028374
 protein coding gene Chr4:110463744-110506308 (+)
LP/J MGP_LPJ_G0028507
 protein coding gene Chr4:115970165-116015048 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028399
 protein coding gene Chr4:128506334-128549684 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029055
 protein coding gene Chr4:114902230-114945615 (+)
PWK/PhJ MGP_PWKPhJ_G0027451
 protein coding gene Chr4:108786165-108843854 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027275
 protein coding gene Chr4:111296991-111341229 (+)
WSB/EiJ MGP_WSBEiJ_G0027804
 protein coding gene Chr4:114684094-114727610 (+)



Homology
more
  • Human Ortholog
    STIL, STIL centriolar assembly protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STIL, STIL centriolar assembly protein
  • Synonyms
    MCPH7, SIL
  • Links
    NCBI Gene ID: 6491
    neXtProt AC: NX_Q15468
    UniProt: Q15468

  • Chr Location
    1p33; chr1:47250139-47314896 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STIL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos with various neural tube defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    104
  • cDNA Data
    67
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028718 Ensembl Gene Model | MGI Sequence Detail 43038 C57BL/6J ±  kb
    transcript ENSMUST00000030490 Ensembl | MGI Sequence Detail 5285 Not Applicable  
    polypeptide ENSMUSP00000030490 Ensembl | MGI Sequence Detail 1262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 69
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36044
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:30658 Aplan PD, et al., Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol Cell Biol. 1991 Nov;11(11):5462-9
    • Latest
      J:358048 Moussa AT, et al., STIL overexpression shortens lifespan and reduces tumor formation in mice. PLoS Genet. 2024 Oct 28;20(10):e1011460
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory