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Pxmp2 Gene Detail
Summary
  • Symbol
    Pxmp2
  • Name
    peroxisomal membrane protein 2
  • Synonyms
    22kDa, PMP22
  • Feature Type
    protein coding gene
  • IDs
    MGI:107487
    NCBI Gene: 19301
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110422152-110434036 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    483 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107487
 protein coding gene Chr5:110422148-110434052 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029884
 protein coding gene Chr5:112717849-112732992 (-)
A/J MGP_AJ_G0029849
 protein coding gene Chr5:108355034-108366799 (-)
AKR/J MGP_AKRJ_G0029787
 protein coding gene Chr5:111811278-111823253 (-)
BALB/cJ MGP_BALBcJ_G0029860
 protein coding gene Chr5:109720878-109732598 (-)
C3H/HeJ MGP_C3HHeJ_G0029580
 protein coding gene Chr5:112228510-112240378 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030313
 protein coding gene Chr5:117167640-117181362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027542
 protein coding gene Chr5:103178239-103191469 (-)
CAST/EiJ MGP_CASTEiJ_G0028988
 protein coding gene Chr5:111088127-111099853 (-)
CBA/J MGP_CBAJ_G0029547
 protein coding gene Chr5:121569201-121581467 (-)
DBA/2J MGP_DBA2J_G0029697
 protein coding gene Chr5:108419243-108430962 (-)
FVB/NJ MGP_FVBNJ_G0029654
 protein coding gene Chr5:107092185-107104491 (-)
LP/J MGP_LPJ_G0029785
 protein coding gene Chr5:113279366-113292526 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029685
 protein coding gene Chr5:126220117-126231851 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030354
 protein coding gene Chr5:111234495-111249957 (-)
PWK/PhJ MGP_PWKPhJ_G0028702
 protein coding gene Chr5:107008317-107020337 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028540
 protein coding gene Chr5:108702510-108713304 (-)
WSB/EiJ MGP_WSBEiJ_G0029064
 protein coding gene Chr5:111690222-111702870 (-)



Homology
more
  • Human Ortholog
    PXMP2, peroxisomal membrane protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PXMP2, peroxisomal membrane protein 2
  • Synonyms
    MPV17L3, PMP22
  • Links
    NCBI Gene ID: 5827
    neXtProt AC: NX_Q9NR77
    UniProt: Q9NR77

  • Chr Location
    12q24.33; chr12:132687587-132704985 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display impaired lactation, increased serum urate levels, elevated urinary clearence of urate, and abnormal liver peroxisomal membrane permeability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19301 NCBI Gene Model | MGI Sequence Detail 11885 C57BL/6J ±  kb
    transcript NM_001405245 RefSeq | MGI Sequence Detail 1043 ZRU/MplStud  
    polypeptide P42925 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36055
    References
    more
    • Summaries
      All 35
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:213750 Vapola MH, et al., Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice. Dev Biol. 2014 Jul 1;391(1):66-80
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory