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Luzp1 Gene Detail
Summary
  • Symbol
    Luzp1
  • Name
    leucine zipper protein 1
  • Synonyms
    2700072H04Rik, Luzp
  • Feature Type
    protein coding gene
  • IDs
    MGI:107629
    NCBI Gene: 269593
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136197072-136282091 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1675 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107629
 protein coding gene Chr4:136189892-136282091 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028968
 protein coding gene Chr4:139044004-139133194 (+)
A/J MGP_AJ_G0028927
 protein coding gene Chr4:133106860-133192426 (+)
AKR/J MGP_AKRJ_G0028879
 protein coding gene Chr4:136951913-137039533 (+)
BALB/cJ MGP_BALBcJ_G0028951
 protein coding gene Chr4:133768053-133861492 (+)
C3H/HeJ MGP_C3HHeJ_G0028665
 protein coding gene Chr4:137243753-137328642 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029392
 protein coding gene Chr4:144009322-144098062 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026663
 protein coding gene Chr4:126141586-126231508 (+)
CAST/EiJ MGP_CASTEiJ_G0028097
 protein coding gene Chr4:135389770-135484697 (+)
CBA/J MGP_CBAJ_G0028630
 protein coding gene Chr4:147953351-148045923 (+)
DBA/2J MGP_DBA2J_G0028779
 protein coding gene Chr4:133521563-133607097 (+)
FVB/NJ MGP_FVBNJ_G0028746
 protein coding gene Chr4:132472204-132557333 (+)
LP/J MGP_LPJ_G0028878
 protein coding gene Chr4:139126528-139213341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028772
 protein coding gene Chr4:152127725-152217892 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029430
 protein coding gene Chr4:137435236-137523500 (+)
PWK/PhJ MGP_PWKPhJ_G0027817
 protein coding gene Chr4:130305819-130390721 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027643
 protein coding gene Chr4:133224797-133313005 (+)
WSB/EiJ MGP_WSBEiJ_G0028175
 protein coding gene Chr4:137589169-137676735 (+)



Homology
more
  • Human Ortholog
    LUZP1, leucine zipper protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LUZP1, leucine zipper protein 1
  • Synonyms
    LUZP
  • Links
    NCBI Gene ID: 7798
    neXtProt AC: NX_Q86V48
    UniProt: Q86V48

  • Chr Location
    1p36.12; chr1:23083642-23178152 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene inactivation causes defective neural tube closure (exencephaly) and massive apoptosis in the hindbrain. Despite the incomplete penetrance of NTD, all homozygotes die perinatally due to complex cardiovascular anomalies. Other defects include an eyelid fusion defect, omphalocele and cleft palate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    40
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001089 Ensembl Gene Model | MGI Sequence Detail 85020 C57BL/6J ±  kb
    transcript ENSMUST00000001116 Ensembl | MGI Sequence Detail 7246 Not Applicable  
    polypeptide ENSMUSP00000001116 Ensembl | MGI Sequence Detail 1068 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009982 leucine zipper protein 1
      (term hierarchy)
    • InterPro Domains
      IPR050719 Cortactin-binding and Actin Dynamics Regulator
    • GlyGen
      Q8R4U7 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36203, MGI:1919863, MGI:2140218
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:34242 Sun DS, et al., Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Genomics. 1996 15;36(1):54-62
    • Latest
      J:358295 Fan D, et al., Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling. J Adv Res. 2024 Sep;63:117-128
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory