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Ifna6 Gene Detail
Summary
  • Symbol
    Ifna6
  • Name
    interferon alpha 6
  • Synonyms
    Ifa6, Ifna8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107662
    NCBI Gene: 15969
  • Member of
    Ifna cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:88745653-88746222 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 42.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    10
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107662
 protein coding gene Chr4:88745627-88746269 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0028398
 protein coding gene Chr4:85632123-85632805 (+)
AKR/J MGP_AKRJ_G0028345
 protein coding gene Chr4:87753847-87754489 (+)
BALB/cJ MGP_BALBcJ_G0028416
 protein coding gene Chr4:85853535-85854177 (+)
C3H/HeJ MGP_C3HHeJ_G0028129
 protein coding gene Chr4:88468245-88468907 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028855
 protein coding gene Chr4:92116245-92116814 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028099
 protein coding gene Chr4:94966870-94967482 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0028215
 protein coding gene Chr4:84322005-84322574 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0028245
 protein coding gene Chr4:99943766-99944335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028892
 protein coding gene Chr4:87887069-87887638 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IFNA1, interferon alpha 1
  • Vertebrate Orthologs
    21
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNA1, interferon alpha 1
  • Synonyms
    IFL, IFN, IFNA@, IFNA13, IFN-ALPHA, IFN-alphaD, leIF D
  • Links
    NCBI Gene ID: 3439
    neXtProt AC: NX_P01562
    UniProt: P01562

  • Chr Location
    9p21.3; chr9:21440439-21441316 (+)  GRCh38
  • Human Ortholog
    IFNA10, interferon alpha 10
  • Synonyms
    IFN-alphaC
  • Links
    NCBI Gene ID: 3446
    neXtProt AC: NX_P01566
    UniProt: P01566

  • Chr Location
    9p21.3; chr9:21206181-21207143 (-)  GRCh38
  • Human Ortholog
    IFNA13, interferon alpha 13
  • Links
    NCBI Gene ID: 3447
    neXtProt AC: NX_P01562
    UniProt: P01562

  • Chr Location
    9p21.3; chr9:21367372-21368057 (-)  GRCh38
  • Human Ortholog
    IFNA14, interferon alpha 14
  • Synonyms
    IFN-alphaH, LEIF2H
  • Links
    NCBI Gene ID: 3448
    neXtProt AC: NX_P01570
    UniProt: P01570

  • Chr Location
    9p21.3; chr9:21239002-21240005 (-)  GRCh38
  • Human Ortholog
    IFNA16, interferon alpha 16
  • Synonyms
    IFN-alpha-16, IFN-alphaO
  • Links
    NCBI Gene ID: 3449
    neXtProt AC: NX_P05015
    UniProt: P05015

  • Chr Location
    9p21.3; chr9:21216373-21217311 (-)  GRCh38
  • Human Ortholog
    IFNA17, interferon alpha 17
  • Synonyms
    IFNA, IFN-alphaI, INFA, LEIF2C1
  • Links
    NCBI Gene ID: 3451
    neXtProt AC: NX_P01571
    UniProt: P01571

  • Chr Location
    9p21.3; chr9:21227243-21228222 (-)  GRCh38
  • Human Ortholog
    IFNA2, interferon alpha 2
  • Synonyms
    IFNA, IFNA2B, IFN-alpha-2, IFN-alphaA, leIF A
  • Links
    NCBI Gene ID: 3440
    neXtProt AC: NX_P01563
    UniProt: P01563

  • Chr Location
    9p21.3; chr9:21384255-21385398 (-)  GRCh38
  • Human Ortholog
    IFNA21, interferon alpha 21
  • Synonyms
    IFN-alphaI, leIF-F, LeIF F
  • Links
    NCBI Gene ID: 3452
    neXtProt AC: NX_P01568
    UniProt: P01568

  • Chr Location
    9p21.3; chr9:21165637-21166660 (-)  GRCh38
  • Human Ortholog
    IFNA4, interferon alpha 4
  • Synonyms
    IFN-alpha4a, INFA4
  • Links
    NCBI Gene ID: 3441
    neXtProt AC: NX_P05014
    UniProt: P05014

  • Chr Location
    9p21.3; chr9:21186618-21187587 (-)  GRCh38
  • Human Ortholog
    IFNA5, interferon alpha 5
  • Synonyms
    IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G
  • Links
    NCBI Gene ID: 3442
    neXtProt AC: NX_P01569
    UniProt: P01569

  • Chr Location
    9p21.3; chr9:21304326-21305313 (-)  GRCh38
  • Human Ortholog
    IFNA6, interferon alpha 6
  • Synonyms
    IFN-alphaK
  • Links
    NCBI Gene ID: 3443
    neXtProt AC: NX_P05013
    UniProt: P05013

  • Chr Location
    9p21.3; chr9:21350253-21350956 (-)  GRCh38
  • Human Ortholog
    IFNA7, interferon alpha 7
  • Synonyms
    IFNA-J, IFN-alphaJ
  • Links
    NCBI Gene ID: 3444
    neXtProt AC: NX_P01567
    UniProt: P01567

  • Chr Location
    9p21.3; chr9:21201469-21202205 (-)  GRCh38
  • Human Ortholog
    IFNA8, interferon alpha 8
  • Synonyms
    IFN-alphaB
  • Links
    NCBI Gene ID: 3445
    neXtProt AC: NX_P32881
    UniProt: P32881

  • Chr Location
    9p21.3; chr9:21409117-21410185 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human IFNA1,IFNA17,IFNA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    12 phenotype references
Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000101252 Ensembl Gene Model | MGI Sequence Detail 570 C57BL/6J ±  kb
transcript ENSMUST00000105146 Ensembl | MGI Sequence Detail 570 Not Applicable  
polypeptide ENSMUSP00000100777 Ensembl | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009079 Four-helical cytokine-like, core
    IPR000471 Interferon alpha/beta/delta
  • GlyGen
    P07350 1 site
Molecular
Reagents
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  • All nucleic 12
    Genomic 6
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11207, MGD-MRK-11209, MGD-MRK-36235, MGD-MRK-36237, MGI:107660
References
more
  • Summaries
    All 40
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:7878 Zwarthoff EC, et al., Organization, structure and expression of murine interferon alpha genes. Nucleic Acids Res. 1985 Feb 11;13(3):791-804
  • Latest
    J:324389 Paulsen M, et al., MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice. Front Immunol. 2020;11:572747
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory