About   Help   FAQ
Ifna4 Gene Detail
Summary
  • Symbol
    Ifna4
  • Name
    interferon alpha 4
  • Synonyms
    Ifa4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107664
    NCBI Gene: 15967
  • Member of
    Ifna cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:88760098-88760658 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 42.03 cM
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107664
 protein coding gene Chr4:88760032-88761009 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028437
 protein coding gene Chr4:88744878-88745438 (+)
A/J MGP_AJ_G0028399
 protein coding gene Chr4:85646921-85647481 (+)
AKR/J MGP_AKRJ_G0028346
 protein coding gene Chr4:87760156-87760716 (+)
BALB/cJ MGP_BALBcJ_G0028417
 protein coding gene Chr4:85859859-85860419 (+)
C3H/HeJ MGP_C3HHeJ_G0028130
 protein coding gene Chr4:88487279-88487839 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028857
 protein coding gene Chr4:92134849-92135409 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027571
 protein coding gene Chr4:86323128-86323688 (+)
CBA/J MGP_CBAJ_G0028100
 protein coding gene Chr4:94973444-94974004 (+)
DBA/2J MGP_DBA2J_G0028250
 protein coding gene Chr4:85405947-85406507 (+)
FVB/NJ MGP_FVBNJ_G0028217
 protein coding gene Chr4:84336391-84336951 (+)
LP/J MGP_LPJ_G0028349
 protein coding gene Chr4:89038802-89039362 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028246
 protein coding gene Chr4:99950002-99950562 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028894
 protein coding gene Chr4:87904436-87904994 (+)
PWK/PhJ MGP_PWKPhJ_G0027295
 protein coding gene Chr4:83695265-83695825 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027649
 protein coding gene Chr4:88104005-88104565 (+)



Homology
more
  • Human Ortholog
    IFNA1, interferon alpha 1
  • Vertebrate Orthologs
    23
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNA1, interferon alpha 1
  • Synonyms
    IFL, IFN, IFNA@, IFNA13, IFN-ALPHA, IFN-alphaD, leIF D
  • Links
    NCBI Gene ID: 3439
    neXtProt AC: NX_P01562
    UniProt: P01562

  • Chr Location
    9p21.3; chr9:21440439-21441316 (+)  GRCh38
  • Human Ortholog
    IFNA10, interferon alpha 10
  • Synonyms
    IFN-alphaC
  • Links
    NCBI Gene ID: 3446
    neXtProt AC: NX_P01566
    UniProt: P01566

  • Chr Location
    9p21.3; chr9:21206181-21207143 (-)  GRCh38
  • Human Ortholog
    IFNA13, interferon alpha 13
  • Links
    NCBI Gene ID: 3447
    neXtProt AC: NX_P01562
    UniProt: P01562

  • Chr Location
    9p21.3; chr9:21367372-21368057 (-)  GRCh38
  • Human Ortholog
    IFNA14, interferon alpha 14
  • Synonyms
    IFN-alphaH, LEIF2H
  • Links
    NCBI Gene ID: 3448
    neXtProt AC: NX_P01570
    UniProt: P01570

  • Chr Location
    9p21.3; chr9:21239002-21240005 (-)  GRCh38
  • Human Ortholog
    IFNA16, interferon alpha 16
  • Synonyms
    IFN-alpha-16, IFN-alphaO
  • Links
    NCBI Gene ID: 3449
    neXtProt AC: NX_P05015
    UniProt: P05015

  • Chr Location
    9p21.3; chr9:21216373-21217311 (-)  GRCh38
  • Human Ortholog
    IFNA17, interferon alpha 17
  • Synonyms
    IFNA, IFN-alphaI, INFA, LEIF2C1
  • Links
    NCBI Gene ID: 3451
    neXtProt AC: NX_P01571
    UniProt: P01571

  • Chr Location
    9p21.3; chr9:21227243-21228222 (-)  GRCh38
  • Human Ortholog
    IFNA2, interferon alpha 2
  • Synonyms
    IFNA, IFNA2B, IFN-alpha-2, IFN-alphaA, leIF A
  • Links
    NCBI Gene ID: 3440
    neXtProt AC: NX_P01563
    UniProt: P01563

  • Chr Location
    9p21.3; chr9:21384255-21385398 (-)  GRCh38
  • Human Ortholog
    IFNA21, interferon alpha 21
  • Synonyms
    IFN-alphaI, leIF-F, LeIF F
  • Links
    NCBI Gene ID: 3452
    neXtProt AC: NX_P01568
    UniProt: P01568

  • Chr Location
    9p21.3; chr9:21165637-21166660 (-)  GRCh38
  • Human Ortholog
    IFNA4, interferon alpha 4
  • Synonyms
    IFN-alpha4a, INFA4
  • Links
    NCBI Gene ID: 3441
    neXtProt AC: NX_P05014
    UniProt: P05014

  • Chr Location
    9p21.3; chr9:21186618-21187587 (-)  GRCh38
  • Human Ortholog
    IFNA5, interferon alpha 5
  • Synonyms
    IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G
  • Links
    NCBI Gene ID: 3442
    neXtProt AC: NX_P01569
    UniProt: P01569

  • Chr Location
    9p21.3; chr9:21304326-21305313 (-)  GRCh38
  • Human Ortholog
    IFNA6, interferon alpha 6
  • Synonyms
    IFN-alphaK
  • Links
    NCBI Gene ID: 3443
    neXtProt AC: NX_P05013
    UniProt: P05013

  • Chr Location
    9p21.3; chr9:21350253-21350956 (-)  GRCh38
  • Human Ortholog
    IFNA7, interferon alpha 7
  • Synonyms
    IFNA-J, IFN-alphaJ
  • Links
    NCBI Gene ID: 3444
    neXtProt AC: NX_P01567
    UniProt: P01567

  • Chr Location
    9p21.3; chr9:21201469-21202205 (-)  GRCh38
  • Human Ortholog
    IFNA8, interferon alpha 8
  • Synonyms
    IFN-alphaB
  • Links
    NCBI Gene ID: 3445
    neXtProt AC: NX_P32881
    UniProt: P32881

  • Chr Location
    9p21.3; chr9:21409117-21410185 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human IFNA1,IFNA17,IFNA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Genomic Mutations
    5 involving Ifna4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070904 Ensembl Gene Model | MGI Sequence Detail 561 C57BL/6J ±  kb
transcript ENSMUST00000094973 Ensembl | MGI Sequence Detail 561 Not Applicable  
polypeptide ENSMUSP00000092581 Ensembl | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR009079 Four-helical cytokine-like, core
    IPR000471 Interferon alpha/beta/delta
  • GlyGen
    P07351 1 site
Molecular
Reagents
less
  • All nucleic 13
    Genomic 6
    cDNA 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11205, MGD-MRK-36239
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:7878 Zwarthoff EC, et al., Organization, structure and expression of murine interferon alpha genes. Nucleic Acids Res. 1985 Feb 11;13(3):791-804
  • Latest
    J:349097 Imai T, et al., The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity. 2024 May 7;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory