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Hoxb13 Gene Detail
Summary
  • Symbol
    Hoxb13
  • Name
    homeobox B13
  • Feature Type
    protein coding gene
  • IDs
    MGI:107730
    NCBI Gene: 15408
  • Member of
    Hoxb cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96085142-96087436 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.63 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107730
 protein coding gene Chr11:96085142-96088273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019000
 protein coding gene Chr11:98494302-98497433 (+)
A/J MGP_AJ_G0018968
 protein coding gene Chr11:94477312-94480444 (+)
AKR/J MGP_AKRJ_G0018938
 protein coding gene Chr11:97388170-97391302 (+)
BALB/cJ MGP_BALBcJ_G0018941
 protein coding gene Chr11:94963043-94966174 (+)
C3H/HeJ MGP_C3HHeJ_G0018755
 protein coding gene Chr11:97528678-97531809 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019393
 protein coding gene Chr11:101582476-101585607 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017023
 protein coding gene Chr11:91964557-91967769 (+)
CAST/EiJ MGP_CASTEiJ_G0018308
 protein coding gene Chr11:98351616-98354749 (+)
CBA/J MGP_CBAJ_G0018726
 protein coding gene Chr11:105735824-105738956 (+)
DBA/2J MGP_DBA2J_G0018834
 protein coding gene Chr11:94046937-94050068 (+)
FVB/NJ MGP_FVBNJ_G0018823
 protein coding gene Chr11:93522292-93525423 (+)
LP/J MGP_LPJ_G0018904
 protein coding gene Chr11:99033641-99036772 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018850
 protein coding gene Chr11:105722745-105725876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019433
 protein coding gene Chr11:97695819-97698950 (+)
PWK/PhJ MGP_PWKPhJ_G0018080
 protein coding gene Chr11:95001314-95004445 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017869
 protein coding gene Chr11:97423197-97426341 (+)
WSB/EiJ MGP_WSBEiJ_G0018358
 protein coding gene Chr11:97588958-97592089 (+)



Homology
more
  • Human Ortholog
    HOXB13, homeobox B13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXB13, homeobox B13
  • Synonyms
    HPC9, PSGD
  • Links
    NCBI Gene ID: 10481
    neXtProt AC: NX_Q92826
    UniProt: Q92826

  • Chr Location
    17q21.32; chr17:48724763-48728750 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HOXB13 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for loss of function mutations show overgrowth in all major structures derived from the tail bud.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    148
  • cDNA Data
    33
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15408 NCBI Gene Model | MGI Sequence Detail 2295 C57BL/6J ±  kb
    transcript NM_008267 RefSeq | MGI Sequence Detail 1369 ZRU/MplStud  
    polypeptide P70321 UniProt | EBI | MGI Sequence Detail 286 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 3
      cDNA 36
      Primer pair 7
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36306
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 28
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:34769 Zeltser L, et al., Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development. 1996 Aug;122(8):2475-84
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory