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Dctn2 Gene Detail
Summary
  • Symbol
    Dctn2
  • Name
    dynactin 2
  • Synonyms
    2310042E05Rik, C130077D06Rik, DCTN-50, p50, RBP50
  • Feature Type
    protein coding gene
  • IDs
    MGI:107733
    NCBI Gene: 69654
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127102237-127117819 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107733
 protein coding gene Chr10:127102131-127117828 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017814
 protein coding gene Chr10:130853820-130872414 (+)
A/J MGP_AJ_G0017789
 protein coding gene Chr10:125611621-125627318 (+)
AKR/J MGP_AKRJ_G0017752
 protein coding gene Chr10:129325961-129341654 (+)
BALB/cJ MGP_BALBcJ_G0017753
 protein coding gene Chr10:126023076-126038857 (+)
C3H/HeJ MGP_C3HHeJ_G0017577
 protein coding gene Chr10:129477945-129494513 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018208
 protein coding gene Chr10:135290523-135307871 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015888
 protein coding gene Chr10:119620244-119636130 (+)
CAST/EiJ MGP_CASTEiJ_G0017137
 protein coding gene Chr10:130136395-130151933 (+)
CBA/J MGP_CBAJ_G0017546
 protein coding gene Chr10:140740175-140759646 (+)
DBA/2J MGP_DBA2J_G0017652
 protein coding gene Chr10:124704094-124719793 (+)
FVB/NJ MGP_FVBNJ_G0017647
 protein coding gene Chr10:123644450-123660203 (+)
LP/J MGP_LPJ_G0017726
 protein coding gene Chr10:131424200-131441315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017675
 protein coding gene Chr10:143444732-143463206 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018248
 protein coding gene Chr10:129391520-129408059 (+)
PWK/PhJ MGP_PWKPhJ_G0016922
 protein coding gene Chr10:124906681-124922873 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016714
 protein coding gene Chr10:128428188-128443899 (+)
WSB/EiJ MGP_WSBEiJ_G0017198
 protein coding gene Chr10:129621293-129637061 (+)



Homology
more
  • Human Ortholog
    DCTN2, dynactin subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCTN2, dynactin subunit 2
  • Synonyms
    DCTN50, DYNAMITIN, HEL-S-77, RBP50
  • Links
    NCBI Gene ID: 10540
    neXtProt AC: NX_Q13561
    UniProt: Q13561

  • Chr Location
    12q13.3; chr12:57529633-57547224 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1011
  • Tissues
    73
  • cDNA Data
    219
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025410 Ensembl Gene Model | MGI Sequence Detail 15583 C57BL/6J ±  kb
transcript ENSMUST00000026479 Ensembl | MGI Sequence Detail 1784 Not Applicable  
polypeptide ENSMUSP00000026479 Ensembl | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 220
    cDNA 220

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36309, MGI:1916904, MGI:2143947, MGI:2444215
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory