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Dctn1 Gene Detail
Summary
  • Symbol
    Dctn1
  • Name
    dynactin 1
  • Synonyms
    Glued, p150, p150glued
  • Feature Type
    protein coding gene
  • IDs
    MGI:107745
    NCBI Gene: 13191
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83142902-83177099 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    829 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107745
 protein coding gene Chr6:83142702-83177103 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030926
 protein coding gene Chr6:84172663-84207785 (+)
A/J MGP_AJ_G0030895
 protein coding gene Chr6:80958455-80993953 (+)
AKR/J MGP_AKRJ_G0030823
 protein coding gene Chr6:83292871-83326885 (+)
BALB/cJ MGP_BALBcJ_G0030905
 protein coding gene Chr6:80978447-81013360 (+)
C3H/HeJ MGP_C3HHeJ_G0030805
 protein coding gene Chr6:101059375-101093581 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031365
 protein coding gene Chr6:86460200-86494406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028551
 protein coding gene Chr6:79317524-79351680 (+)
CAST/EiJ MGP_CASTEiJ_G0030014
 protein coding gene Chr6:83302371-83339240 (+)
CBA/J MGP_CBAJ_G0030592
 protein coding gene Chr6:89878449-89915802 (+)
DBA/2J MGP_DBA2J_G0030745
 protein coding gene Chr6:80277296-80311730 (+)
FVB/NJ MGP_FVBNJ_G0030698
 protein coding gene Chr6:79484754-79519003 (+)
LP/J MGP_LPJ_G0030824
 protein coding gene Chr6:84167497-84209341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030734
 protein coding gene Chr6:94188334-94225529 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031389
 protein coding gene Chr6:83107752-83144325 (+)
PWK/PhJ MGP_PWKPhJ_G0029729
 protein coding gene Chr6:79171387-79206320 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029557
 protein coding gene Chr6:81951185-81985224 (+)
WSB/EiJ MGP_WSBEiJ_G0030095
 protein coding gene Chr6:83542627-83577923 (+)



Homology
more
  • Human Ortholog
    DCTN1, dynactin subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCTN1, dynactin subunit 1
  • Synonyms
    DAP-150, DP-150, HMND14, P135
  • Links
    NCBI Gene ID: 1639
    neXtProt AC: NX_Q14203
    UniProt: Q14203

  • Chr Location
    2p13.1; chr2:74361154-74392087 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human DCTN1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality and developmental arrest at E7.5 associated with increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    105
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    8
  • cDNA Data
    207
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031865 Ensembl Gene Model | MGI Sequence Detail 34198 C57BL/6J ±  kb
    transcript ENSMUST00000113919 Ensembl | MGI Sequence Detail 4292 Not Applicable  
    polypeptide ENSMUSP00000109552 Ensembl | MGI Sequence Detail 1281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 212
      Genomic 3
      cDNA 209

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36321, MGI:2144338
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 15
      Gene Ontology 23
      Phenotypes 18
    • Earliest
      J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory