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Atp5f1b Gene Detail
Summary
  • Symbol
    Atp5f1b
  • Name
    ATP synthase F1 subunit beta
  • Synonyms
    Atp5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107801
    NCBI Gene: 11947
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127919176-127926257 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107801
 protein coding gene Chr10:127919142-127926260 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017847
 protein coding gene Chr10:131758823-131766995 (+)
A/J MGP_AJ_G0017822
 protein coding gene Chr10:126486771-126493889 (+)
AKR/J MGP_AKRJ_G0017785
 protein coding gene Chr10:130217932-130225068 (+)
BALB/cJ MGP_BALBcJ_G0017786
 protein coding gene Chr10:126870612-126878682 (+)
C3H/HeJ MGP_C3HHeJ_G0017609
 protein coding gene Chr10:130371366-130379192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018241
 protein coding gene Chr10:136244265-136251273 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015919
 protein coding gene Chr10:120451080-120457779 (+)
CAST/EiJ MGP_CASTEiJ_G0017170
 protein coding gene Chr10:131073610-131080534 (+)
CBA/J MGP_CBAJ_G0017579
 protein coding gene Chr10:141753971-141777104 (+)
DBA/2J MGP_DBA2J_G0017685
 protein coding gene Chr10:125560898-125568320 (+)
FVB/NJ MGP_FVBNJ_G0017680
 protein coding gene Chr10:124495252-124502290 (+)
LP/J MGP_LPJ_G0017759
 protein coding gene Chr10:132374849-132381975 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017708
 protein coding gene Chr10:144361206-144368324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018281
 protein coding gene Chr10:130301530-130309011 (+)
PWK/PhJ MGP_PWKPhJ_G0016955
 protein coding gene Chr10:125811245-125818345 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016744
 protein coding gene Chr10:129385313-129392283 (+)
WSB/EiJ MGP_WSBEiJ_G0017229
 protein coding gene Chr10:130517806-130525475 (+)



Homology
more
  • Human Ortholog
    ATP5F1B, ATP synthase F1 subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP5F1B, ATP synthase F1 subunit beta
  • Synonyms
    ATP5B, ATPMB, ATPSB, HEL-S-271, HUMOP2
  • Links
    NCBI Gene ID: 506
    neXtProt AC: NX_P06576
    UniProt: P06576

  • Chr Location
    12q13.3; chr12:56638175-56645984 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    59
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    138
  • cDNA Data
    1609
  • Literature Summary
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11947 NCBI Gene Model | MGI Sequence Detail 7082 C57BL/6J ±  kb
transcript NM_016774 RefSeq | MGI Sequence Detail 1879 C57BL/6  
polypeptide P56480 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004454 ATP synthase subunit beta, mitochondrial
    (term hierarchy)
  • EC
    7.1.2.2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR050053 ATPase alpha/beta chains
    IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site
    IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
    IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
    IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
    IPR024034 ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
    IPR005722 ATP synthase, F1 complex, beta subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    P56480 4 sites, 1 O-linked glycan (3 sites)
Molecular
Reagents
less
  • All nucleic 1612
    cDNA 1609
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-36378, MGI:7469633
References
more
  • Summaries
    All 82
    Developmental Gene Expression 14
    Gene Ontology 18
    Phenotypes 17
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:359001 Hu Y, et al., Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation. Cell Rep. 2024 Oct 22;43(10):114839
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory