Rock2 MGI Mouse Gene Detail - MGI:107926 - Rho-associated coiled-coil containing protein kinase 2

Symbol

Rock2
Name

Rho-associated coiled-coil containing protein kinase 2
Synonyms

B230113H15Rik, Rho-kinase, Rock2m, Rock-II, ROKalpha

Feature Type

protein coding gene
IDs

MGI:107926
NCBI Gene: 19878
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr12:16944896-17037824 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.04 cM, cytoband A3
Mapping Data

4 experiments

SNPs within 2kb

1701 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107926	protein coding gene	Chr12:16944808-17038275 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019613	protein coding gene	Chr12:14300107-14395162 (+)
A/J	MGP_AJ_G0019580	protein coding gene	Chr12:13800353-13894653 (+)
AKR/J	MGP_AKRJ_G0019550	protein coding gene	Chr12:14455779-14548614 (+)
BALB/cJ	MGP_BALBcJ_G0019556	protein coding gene	Chr12:14047158-14139974 (+)
C3H/HeJ	MGP_C3HHeJ_G0019361	protein coding gene	Chr12:14360965-14460430 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020004	protein coding gene	Chr12:14775491-14882280 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017630	protein coding gene	Chr12:13305779-13399973 (+)
CAST/EiJ	MGP_CASTEiJ_G0018916	protein coding gene	Chr12:14244657-14344025 (+)
CBA/J	MGP_CBAJ_G0019332	protein coding gene	Chr12:15583561-15681772 (+)
DBA/2J	MGP_DBA2J_G0019445	protein coding gene	Chr12:13715282-13811671 (+)
FVB/NJ	MGP_FVBNJ_G0019436	protein coding gene	Chr12:13603877-13699183 (+)
LP/J	MGP_LPJ_G0019516	protein coding gene	Chr12:14419382-14515249 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019471	protein coding gene	Chr12:15463891-15568125 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020043	protein coding gene	Chr12:14142446-14237379 (+)
PWK/PhJ	MGP_PWKPhJ_G0018682	protein coding gene	Chr12:13753761-13849428 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018472	protein coding gene	Chr12:14352707-14446508 (+)
WSB/EiJ	MGP_WSBEiJ_G0018967	protein coding gene	Chr12:14256412-14358866 (+)

Human Ortholog

ROCK2, Rho associated coiled-coil containing protein kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ROCK2, Rho associated coiled-coil containing protein kinase 2
Synonyms

ROCK-II
Links

HGNC:10252

NCBI Gene ID: 9475

neXtProt AC: NX_O75116

UniProt: O75116
Chr Location

2p25.1; chr2:11179759-11348330 (-) GRCh38

MGI Vertebrate Homology

Rock2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ROCK2
Protein SuperFamily

Rho_kinase
Gene Tree

Rock2

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Phenotype Summary

35 phenotypes from 6 alleles in 7 genetic backgrounds
1 phenotype from multigenic genotypes
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

2
Gene trapped

6
Targeted

15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this genes tend to die before birth; those that survive are small. Hemorrhaging occurs in the placenta, at the tips of hind limb buds and occasionally the tail. Subsequent development is normal and the size deficit is made up. They are fertile as adults.

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All GO Annotations

129
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

880
Tissues

92
cDNA Data

187
Literature Summary

27

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ROCK2

Xenbase rock2

ZFIN rock2a, rock2b

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All Sequences

72
RefSeq

14
UniProt

9
CCDS

CCDS36410.1

Ensembl

ENSMUSG00000020580 (Evidence)
NCBI Gene

19878

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020580	Ensembl Gene Model \| MGI Sequence Detail	92929	C57BL/6J	± kb
transcript	ENSMUST00000220688	Ensembl \| MGI Sequence Detail	4357	Not Applicable
polypeptide	ENSMUSP00000152813	Ensembl \| MGI Sequence Detail	1444	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000000121 Rho-associated protein kinase 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR011072 HR1 rho-binding domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR020684 Rho-associated protein kinase 1/2

IPR029878 Rho-associated protein kinase 2, catalytic domain

IPR037311 Rho-associated protein kinase 2, HR1 domain

IPR050839 Rho-associated Serine/Threonine Kinase

IPR015008 ROCK, Rho binding domain

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P70336 1 site, 7 N-linked glycans (1 site)

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All nucleic 194

cDNA 188

Primer pair 6

Microarray probesets 4

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MGD-MRK-36506, MGI:1925098

Summaries

All 169

Developmental Gene Expression 27

Gene Ontology 27

Phenotypes 43
Earliest

J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
Latest

J:359176 Funahashi Y, et al., Signal flow in the NMDA receptor-dependent phosphoproteome regulates postsynaptic plasticity for aversive learning. Sci Signal. 2024 Sep 10;17(853):eado9852

TSS for Rock2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112861	Chr12:16944828-16944888 (+)	-38 bp
Tssr112862	Chr12:16944895-16944905 (+)	4 bp
Tssr112863	Chr12:16945083-16945091 (+)	191 bp
Tssr112864	Chr12:16945118-16945133 (+)	230 bp
Tssr112865	Chr12:16954963-16954988 (+)	10,080 bp
Tssr112866	Chr12:16959483-16959486 (+)	14,589 bp
Tssr112867	Chr12:16960470-16960475 (+)	15,577 bp
Tssr112868	Chr12:16992834-16992888 (+)	47,965 bp
Tssr112869	Chr12:17008690-17008704 (+)	63,801 bp
Tssr112870	Chr12:17015036-17015066 (+)	70,155 bp
Tssr112871	Chr12:17015123-17015156 (+)	70,244 bp
Tssr112872	Chr12:17015491-17015566 (+)	70,633 bp
Tssr112873	Chr12:17016169-17016180 (+)	71,279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24