About   Help   FAQ
Sqstm1 Gene Detail
Summary
  • Symbol
    Sqstm1
  • Name
    sequestosome 1
  • Synonyms
    A170, OSF-6, Osi, p62, STAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107931
    NCBI Gene: 18412
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:50090193-50101654 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 30.36 cM, cytoband B1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107931
 protein coding gene Chr11:50090193-50105303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018243
 protein coding gene Chr11:49364110-49377193 (-)
A/J MGP_AJ_G0018211
 protein coding gene Chr11:47470785-47483223 (-)
AKR/J MGP_AKRJ_G0018181
 protein coding gene Chr11:48982849-48994249 (-)
BALB/cJ MGP_BALBcJ_G0018181
 protein coding gene Chr11:47751054-47762569 (-)
C3H/HeJ MGP_C3HHeJ_G0017994
 protein coding gene Chr11:48989005-49000632 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018632
 protein coding gene Chr11:50826600-50839323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016284
 protein coding gene Chr11:45091540-45102538 (-)
CAST/EiJ MGP_CASTEiJ_G0017556
 protein coding gene Chr11:48948783-48970377 (-)
CBA/J MGP_CBAJ_G0017969
 protein coding gene Chr11:53188464-53199896 (-)
DBA/2J MGP_DBA2J_G0018076
 protein coding gene Chr11:47271181-47282626 (-)
FVB/NJ MGP_FVBNJ_G0018070
 protein coding gene Chr11:46895544-46907490 (-)
LP/J MGP_LPJ_G0018151
 protein coding gene Chr11:49699154-49710585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018095
 protein coding gene Chr11:54713177-54725934 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018676
 protein coding gene Chr11:49089559-49101056 (-)
PWK/PhJ MGP_PWKPhJ_G0017334
 protein coding gene Chr11:47662037-47682622 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017129
 protein coding gene Chr11:48782019-48796356 (-)
WSB/EiJ MGP_WSBEiJ_G0017609
 protein coding gene Chr11:48728966-48740434 (-)



Homology
more
  • Human Ortholog
    SQSTM1, sequestosome 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SQSTM1, sequestosome 1
  • Synonyms
    A170, DMRV, EBIAP, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3
  • Links
    NCBI Gene ID: 8878
    neXtProt AC: NX_Q13501
    UniProt: Q13501

  • Chr Location
    5q35.3; chr5:179806393-179838078 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sqstm1 mouse models; 5 with human SQSTM1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 10 alleles in 14 genetic backgrounds
    13 phenotypes from multigenic genotypes
    3 images
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit impaired osteoclastogenesis in response to osteoclastogenic factors. Mice homozygous and heterozygous for a knock-in allele exhibit osteolytic lesion with increased bone formation, mineral apposition rate,and osteoclast numbers. Heterozygosity for the hyperactivating p.S351E mutation leads to hyperkeratosis in stomach and esophagus and, consequently, malnutrition, dehydration and severe growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    133
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1007
  • Tissues
    161
  • cDNA Data
    11
  • Literature Summary
    80
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015837 Ensembl Gene Model | MGI Sequence Detail 11462 C57BL/6J ±  kb
    transcript ENSMUST00000102774 Ensembl | MGI Sequence Detail 2037 Not Applicable  
    polypeptide ENSMUSP00000099835 Ensembl | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 12
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36511
    References
    more
    • Summaries
      All 336
      Developmental Gene Expression 80
      Diseases 3
      Gene Ontology 31
      Phenotypes 127
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357377 Ghosh R, et al., Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1alpha and nuclear factor erythroid 2-related factor 2. Cardiovasc Res. 2024 Apr 30;120(5):531-547
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory