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Zfp36l1 Gene Detail
Summary
  • Symbol
    Zfp36l1
  • Name
    zinc finger protein 36, C3H type-like 1
  • Synonyms
    Brf1, cMG1, D530020L18Rik, TIS11b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107946
    NCBI Gene: 12192
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80154534-80159787 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 36.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107946
 protein coding gene Chr12:80154528-80159787 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019885
 protein coding gene Chr12:80446678-80452178 (-)
A/J MGP_AJ_G0019843
 protein coding gene Chr12:77540717-77546047 (-)
AKR/J MGP_AKRJ_G0019818
 protein coding gene Chr12:79645542-79652874 (-)
BALB/cJ MGP_BALBcJ_G0019822
 protein coding gene Chr12:77792566-77798928 (-)
C3H/HeJ MGP_C3HHeJ_G0019628
 protein coding gene Chr12:80123261-80129139 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020274
 protein coding gene Chr12:82808495-82813763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017893
 protein coding gene Chr12:74549419-74554644 (-)
CAST/EiJ MGP_CASTEiJ_G0019178
 protein coding gene Chr12:74980150-74984187 (-)
CBA/J MGP_CBAJ_G0019599
 protein coding gene Chr12:86045905-86055056 (-)
DBA/2J MGP_DBA2J_G0019714
 protein coding gene Chr12:77162951-77167094 (-)
FVB/NJ MGP_FVBNJ_G0019700
 protein coding gene Chr12:75974063-75979340 (-)
LP/J MGP_LPJ_G0019786
 protein coding gene Chr12:80379121-80384997 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019739
 protein coding gene Chr12:89076036-89082144 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020309
 protein coding gene Chr12:79174483-79180363 (-)
PWK/PhJ MGP_PWKPhJ_G0018944
 protein coding gene Chr12:71545378-71550954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018738
 protein coding gene Chr12:73662324-73668918 (-)
WSB/EiJ MGP_WSBEiJ_G0019231
 protein coding gene Chr12:79797294-79804825 (-)



Homology
more
  • Human Ortholog
    ZFP36L1, ZFP36 ring finger protein like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFP36L1, ZFP36 ring finger protein like 1
  • Synonyms
    Berg36, BRF1, cMG1, ERF-1, ERF1, RNF162B, TIS11B
  • Links
    NCBI Gene ID: 677
    neXtProt AC: NX_Q07352
    UniProt: Q07352

  • Chr Location
    14q24.1; chr14:68787655-68796253 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with failure of chorioallantoic fusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    108
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1501
  • Tissues
    163
  • cDNA Data
    143
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12192 NCBI Gene Model | MGI Sequence Detail 5254 C57BL/6J ±  kb
    transcript NM_007564 RefSeq | MGI Sequence Detail 2984 C57BL/6  
    polypeptide P23950 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      cDNA 144
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36526, MGI:1925964, MGI:2140615, MGI:2145053
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 18
      Phenotypes 25
    • Earliest
      J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
    • Latest
      J:353310 Petkau G, et al., Zfp36l1 establishes the high-affinity CD8 T-cell response by directly linking TCR affinity to cytokine sensing. Eur J Immunol. 2024;54(2):e2350700
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory