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Slc8a2 Gene Detail
Summary
  • Symbol
    Slc8a2
  • Name
    solute carrier family 8 (sodium/calcium exchanger), member 2
  • Synonyms
    Ncx2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107996
    NCBI Gene: 110891
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15863751-15894988 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    825 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107996
 protein coding gene Chr7:15861540-15894988 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031700
 protein coding gene Chr7:13785775-13817512 (+)
A/J MGP_AJ_G0031672
 protein coding gene Chr7:13591181-13622740 (+)
AKR/J MGP_AKRJ_G0031597
 protein coding gene Chr7:13893117-13923251 (+)
BALB/cJ MGP_BALBcJ_G0031679
 protein coding gene Chr7:13690592-13721061 (+)
C3H/HeJ MGP_C3HHeJ_G0031401
 protein coding gene Chr7:14067488-14098146 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032145
 protein coding gene Chr7:14541862-14574697 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029224
 protein coding gene Chr7:15148103-15178436 (+)
CAST/EiJ MGP_CASTEiJ_G0030752
 protein coding gene Chr7:10838219-10870392 (+)
CBA/J MGP_CBAJ_G0031360
 protein coding gene Chr7:14987233-15023061 (+)
DBA/2J MGP_DBA2J_G0031516
 protein coding gene Chr7:13477678-13507549 (+)
FVB/NJ MGP_FVBNJ_G0031472
 protein coding gene Chr7:13362229-13397066 (+)
LP/J MGP_LPJ_G0031601
 protein coding gene Chr7:14057889-14091736 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031507
 protein coding gene Chr7:14967305-14998609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032174
 protein coding gene Chr7:13668919-13700745 (+)
PWK/PhJ MGP_PWKPhJ_G0030476
 protein coding gene Chr7:10985466-11017154 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030304
 protein coding gene Chr7:8599662-8634656 (+)
WSB/EiJ MGP_WSBEiJ_G0030849
 protein coding gene Chr7:13704990-13736609 (+)



Homology
more
  • Human Ortholog
    SLC8A2, solute carrier family 8 member A2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC8A2, solute carrier family 8 member A2
  • Synonyms
    NCX2
  • Links
    NCBI Gene ID: 6543
    neXtProt AC: NX_Q9UPR5
    UniProt: Q9UPR5

  • Chr Location
    19q13.32; chr19:47428017-47471893 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The clearance of elevated calcium following depolarization is delayed in homozygous mutant mice, which exhibit enhanced learning and memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    5
  • cDNA Data
    6
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030376 Ensembl Gene Model | MGI Sequence Detail 31238 C57BL/6J ±  kb
    transcript ENSMUST00000211649 Ensembl | MGI Sequence Detail 5261 Not Applicable  
    polypeptide ENSMUSP00000147497 Ensembl | MGI Sequence Detail 921 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36576
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:47387 Li Z, et al., Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger. J Biol Chem. 1994 Jul 1;269(26):17434-9
    • Latest
      J:338690 Kon N, et al., Na(+)/Ca(2+) exchanger mediates cold Ca(2+) signaling conserved for temperature-compensated circadian rhythms. Sci Adv. 2021 Apr;7(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory