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Uncx Gene Detail
Summary
  • Symbol
    Uncx
  • Name
    UNC homeobox
  • Synonyms
    Chx4, Uncx4.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108013
    NCBI Gene: 22255
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139529620-139533934 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.75 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108013
 protein coding gene Chr5:139529249-139533934 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030287
 protein coding gene Chr5:144538065-144542707 (+)
A/J MGP_AJ_G0030256
 protein coding gene Chr5:138408025-138412573 (+)
AKR/J MGP_AKRJ_G0030188
 protein coding gene Chr5:142717506-142722152 (+)
BALB/cJ MGP_BALBcJ_G0030273
 protein coding gene Chr5:139648456-139653098 (+)
C3H/HeJ MGP_C3HHeJ_G0029984
 protein coding gene Chr5:143494777-143499419 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030718
 protein coding gene Chr5:149864726-149869412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027936
 protein coding gene Chr5:132265723-132270419 (+)
CAST/EiJ MGP_CASTEiJ_G0029389
 protein coding gene Chr5:142907517-142912194 (+)
CBA/J MGP_CBAJ_G0029954
 protein coding gene Chr5:156054133-156058649 (+)
DBA/2J MGP_DBA2J_G0030104
 protein coding gene Chr5:138213318-138218367 (+)
FVB/NJ MGP_FVBNJ_G0030059
 protein coding gene Chr5:137332237-137336757 (+)
LP/J MGP_LPJ_G0030190
 protein coding gene Chr5:145146092-145151329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030090
 protein coding gene Chr5:158693182-158697824 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030758
 protein coding gene Chr5:142534936-142539576 (+)
PWK/PhJ MGP_PWKPhJ_G0029104
 protein coding gene Chr5:137229144-137233775 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028940
 protein coding gene Chr5:140220584-140225250 (+)
WSB/EiJ MGP_WSBEiJ_G0029463
 protein coding gene Chr5:143305494-143311874 (+)



Homology
more
  • Human Ortholog
    UNCX, UNC homeobox
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNCX, UNC homeobox
  • Synonyms
    UNCX4.1
  • Links
    NCBI Gene ID: 340260
    neXtProt AC: NX_A6NJT0
    UniProt: A6NJT0

  • Chr Location
    7p22.3; chr7:1232872-1237326 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit severe skeletal defects, including absence of pedicles, transverse processes and proximal ribs. Mutants die around birth from respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1390
  • Tissues
    235
  • cDNA Data
    23
  • Literature Summary
    225
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22255 NCBI Gene Model | MGI Sequence Detail 4315 C57BL/6J ±  kb
    transcript NM_013702 RefSeq | MGI Sequence Detail 2095 C57BL/6  
    polypeptide O08934 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 1
      cDNA 25
      Primer pair 7
      Other 30

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37047
    References
    more
    • Summaries
      All 252
      Developmental Gene Expression 225
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:33997 Bulleit RF, et al., A novel gene selectively expressed in the cerebellum. Neurosci Lett. 1996 May 10;209(2):93-6
    • Latest
      J:348800 Clark JF, et al., Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. Genes Dev. 2024 Jun 4;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory