Pkn1 MGI Mouse Gene Detail - MGI:108022

Symbol

Pkn1
Name

protein kinase N1
Synonyms

F730027O18Rik, PAK1, Pkn, PRK1, Prkcl1, Stk3

Feature Type

protein coding gene
IDs

MGI:108022
NCBI Gene: 320795
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr8:84393165-84425808 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 40.22 cM
Mapping Data

5 experiments

SNPs within 2kb

682 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108022	protein coding gene	Chr8:84393162-84425819 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033838	protein coding gene	Chr8:84509266-84542294 (-)
A/J	MGP_AJ_G0033821	protein coding gene	Chr8:81209735-81239089 (-)
AKR/J	MGP_AKRJ_G0033747	protein coding gene	Chr8:83599164-83631300 (-)
BALB/cJ	MGP_BALBcJ_G0033814	protein coding gene	Chr8:81306583-81338979 (-)
C3H/HeJ	MGP_C3HHeJ_G0033524	protein coding gene	Chr8:84223421-84253389 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034334	protein coding gene	Chr8:87732064-87762386 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031276	protein coding gene	Chr8:74992012-75022760 (-)
CAST/EiJ	MGP_CASTEiJ_G0032854	protein coding gene	Chr8:83622375-83658767 (-)
CBA/J	MGP_CBAJ_G0033502	protein coding gene	Chr8:90879896-90921376 (-)
DBA/2J	MGP_DBA2J_G0033655	protein coding gene	Chr8:80847480-80878807 (-)
FVB/NJ	MGP_FVBNJ_G0033601	protein coding gene	Chr8:79759902-79790065 (-)
LP/J	MGP_LPJ_G0033745	protein coding gene	Chr8:84616517-84645929 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033643	protein coding gene	Chr8:93378212-93410778 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034351	protein coding gene	Chr8:83575931-83605259 (-)
PWK/PhJ	MGP_PWKPhJ_G0032558	protein coding gene	Chr8:80061124-80091160 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032395	protein coding gene	Chr8:82376922-82406437 (-)
WSB/EiJ	MGP_WSBEiJ_G0032967	protein coding gene	Chr8:83980393-84012853 (-)

Human Ortholog

PKN1, protein kinase N1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PKN1, protein kinase N1
Synonyms

DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
Links

HGNC:9405

NCBI Gene ID: 5585

neXtProt AC: NX_Q16512

UniProt: Q16512
Chr Location

19p13.12; chr19:14433053-14471867 (+) GRCh38

MGI Vertebrate Homology

Pkn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PKN1
Gene Tree

Pkn1

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Phenotype Summary

36 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
2 images
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Pkn1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show spontaneous germinal center formation and autoantibody production and develop glomerulonephritis. Homozygotes for a different null allele have mild systolic and diastolic dysfunction, and show increased myocardial infarction size after ischemia-reperfusion injury.

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All GO Annotations

63
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

764
Tissues

38
cDNA Data

16
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pkn1

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All Sequences

61
RefSeq

9
UniProt

2
CCDS

CCDS22459.1, CCDS57627.1

Ensembl

ENSMUSG00000057672 (Evidence)
NCBI Gene

320795

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057672	Ensembl Gene Model \| MGI Sequence Detail	32644	C57BL/6J	± kb
transcript	ENSMUST00000144258	Ensembl \| MGI Sequence Detail	2995	Not Applicable
polypeptide	ENSMUSP00000116235	Ensembl \| MGI Sequence Detail	951	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012785 serine/threonine-protein kinase N1

(term hierarchy)
EC

2.7.11.13
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR036274 HR1 repeat superfamily

IPR011072 HR1 rho-binding domain

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR037317 Serine/threonine-protein kinase N1, second HR1 domain

IPR037784 Serine/threonine-protein kinase N, C2 domain

IPR037313 Serine/threonine-protein kinase N, first HR1 domain

IPR050236 Serine/threonine-protein kinases, AGC
GlyGen

P70268 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 22

Genomic 2

cDNA 20

Microarray probesets 5

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MGD-MRK-37058, MGI:2444757

Summaries

All 90

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 52
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pkn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82047	Chr8:84425724-84425835 (-)	28 bp
Tssr82046	Chr8:84420633-84420673 (-)	5,155 bp
Tssr82045	Chr8:84416736-84416741 (-)	9,069 bp
Tssr82044	Chr8:84409981-84409991 (-)	15,822 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24