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Gpr65 Gene Detail
Summary
  • Symbol
    Gpr65
  • Name
    G-protein coupled receptor 65
  • Synonyms
    Dig1, Gpcr25, TDAG8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108031
    NCBI Gene: 14744
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:98234894-98242903 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 49.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108031
 protein coding gene Chr12:98234894-98242981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020004
 protein coding gene Chr12:99635224-99643887 (+)
A/J MGP_AJ_G0019959
 protein coding gene Chr12:95912813-95920804 (+)
AKR/J MGP_AKRJ_G0019935
 protein coding gene Chr12:98502013-98510018 (+)
BALB/cJ MGP_BALBcJ_G0019945
 protein coding gene Chr12:96240002-96248201 (+)
C3H/HeJ MGP_C3HHeJ_G0019747
 protein coding gene Chr12:99032625-99041136 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020394
 protein coding gene Chr12:102659358-102667296 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018008
 protein coding gene Chr12:92888436-92896456 (+)
CAST/EiJ MGP_CASTEiJ_G0019293
 protein coding gene Chr12:94090242-94098367 (+)
CBA/J MGP_CBAJ_G0019719
 protein coding gene Chr12:106481340-106490824 (+)
DBA/2J MGP_DBA2J_G0019830
 protein coding gene Chr12:95325302-95333313 (+)
FVB/NJ MGP_FVBNJ_G0019819
 protein coding gene Chr12:94047977-94056522 (+)
LP/J MGP_LPJ_G0019906
 protein coding gene Chr12:99460845-99469284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019861
 protein coding gene Chr12:110191874-110200915 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020423
 protein coding gene Chr12:98059536-98067610 (+)
PWK/PhJ MGP_PWKPhJ_G0019057
 protein coding gene Chr12:89928945-89952828 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018853
 protein coding gene Chr12:92233323-92241307 (+)
WSB/EiJ MGP_WSBEiJ_G0019347
 protein coding gene Chr12:98888569-98897753 (+)



Homology
more
  • Human Ortholog
    GPR65, G protein-coupled receptor 65
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR65, G protein-coupled receptor 65
  • Synonyms
    hTDAG8, TDAG8
  • Links
    NCBI Gene ID: 8477
    neXtProt AC: NX_Q8IYL9
    UniProt: Q8IYL9

  • Chr Location
    14q31.3; chr14:88005135-88014811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 5 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    98
  • cDNA Data
    11
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021886 Ensembl Gene Model | MGI Sequence Detail 8010 C57BL/6J ±  kb
    transcript ENSMUST00000075072 Ensembl | MGI Sequence Detail 2069 Not Applicable  
    polypeptide ENSMUSP00000074581 Ensembl | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37067
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 50
    • Earliest
      J:36260 Choi JW, et al., Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol. 1996 Feb 25;168(1):78-84
    • Latest
      J:352140 Neale I, et al., Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Sci Adv. 2024 Jul 19;10(29):eadn2339
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory