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Cnga2 Gene Detail
Summary
  • Symbol
    Cnga2
  • Name
    cyclic nucleotide gated channel alpha 2
  • Synonyms
    Cnca, Cncg4, OCNC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108040
    NCBI Gene: 12789
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:71035455-71053824 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.15 cM, cytoband A6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108040
 protein coding gene ChrX:71035455-71053824 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035789
 protein coding gene ChrX:67674059-67692206 (+)
A/J MGP_AJ_G0035773
 protein coding gene ChrX:67918143-67936133 (+)
AKR/J MGP_AKRJ_G0035695
 protein coding gene ChrX:69724662-69746821 (+)
BALB/cJ MGP_BALBcJ_G0035760
 protein coding gene ChrX:66950510-66968726 (+)
C3H/HeJ MGP_C3HHeJ_G0035463
 protein coding gene ChrX:68184238-68202953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036290
 protein coding gene ChrX:69721612-69741837 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033137
 protein coding gene ChrX:67135479-67153514 (+)
CAST/EiJ MGP_CASTEiJ_G0034755
 protein coding gene ChrX:53574646-53597018 (+)
CBA/J MGP_CBAJ_G0035438
 protein coding gene ChrX:71671241-71689370 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0035542
 protein coding gene ChrX:66744636-66762589 (+)
LP/J MGP_LPJ_G0035680
 protein coding gene ChrX:68534012-68552099 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035577
 protein coding gene ChrX:74232216-74251408 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036311
 protein coding gene ChrX:67524200-67542323 (+)
PWK/PhJ MGP_PWKPhJ_G0034455
 protein coding gene ChrX:51579638-51598594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034290
 protein coding gene ChrX:54484527-54502714 (+)
WSB/EiJ MGP_WSBEiJ_G0034897
 protein coding gene ChrX:66849151-66872441 (+)



Homology
more
  • Human Ortholog
    CNGA2, cyclic nucleotide gated channel subunit alpha 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNGA2, cyclic nucleotide gated channel subunit alpha 2
  • Synonyms
    CNCA, CNCA1, CNG2, OCNC1, OCNCa, OCNCALPHA
  • Links
    NCBI Gene ID: 1260
    neXtProt AC: NX_Q16280
    UniProt: Q16280

  • Chr Location
    Xq28; chrX:151734746-151745564 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 6 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality within 2 days of birth, growth retardation, and abnormal olfactory neuron response to forskolin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    5
  • cDNA Data
    7
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12789 NCBI Gene Model | MGI Sequence Detail 18370 C57BL/6J ±  kb
    transcript NM_001410247 RefSeq | MGI Sequence Detail 3251 C57BL/6  
    polypeptide Q62398 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000000698 cyclic nucleotide-gated olfactory channel
      (term hierarchy)
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR050866 Cyclic Nucleotide-Gated Cation Channel
      IPR032406 Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
      IPR005821 Ion transport domain
      IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2037, MGD-MRK-37076, MGI:88435
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 45
    • Earliest
      J:35001 Ruiz ML, et al., Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart. J Mol Cell Cardiol. 1996 Jul;28(7):1453-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory