About   Help   FAQ
Serpinf1 Gene Detail
Summary
  • Symbol
    Serpinf1
  • Name
    serine (or cysteine) peptidase inhibitor, clade F, member 1
  • Synonyms
    EPC-1, Pedf, Pedfl, pigment epithelium derived factor, Sdf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108080
    NCBI Gene: 20317
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75300855-75313449 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    466 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108080
 protein coding gene Chr11:75300595-75313527 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018710
 protein coding gene Chr11:76154805-76167052 (-)
A/J MGP_AJ_G0018676
 protein coding gene Chr11:73323479-73336426 (-)
AKR/J MGP_AKRJ_G0018646
 protein coding gene Chr11:75537214-75550124 (-)
BALB/cJ MGP_BALBcJ_G0018650
 protein coding gene Chr11:73693388-73706377 (-)
C3H/HeJ MGP_C3HHeJ_G0018463
 protein coding gene Chr11:75554704-75567869 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019101
 protein coding gene Chr11:78530748-78545376 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016736
 protein coding gene Chr11:70330523-70344042 (-)
CAST/EiJ MGP_CASTEiJ_G0018017
 protein coding gene Chr11:75948972-75962720 (-)
CBA/J MGP_CBAJ_G0018433
 protein coding gene Chr11:81970502-81985925 (-)
DBA/2J MGP_DBA2J_G0018542
 protein coding gene Chr11:72929089-72941094 (-)
FVB/NJ MGP_FVBNJ_G0018532
 protein coding gene Chr11:72488693-72500820 (-)
LP/J MGP_LPJ_G0018613
 protein coding gene Chr11:76740051-76752166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018558
 protein coding gene Chr11:82555869-82567904 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019141
 protein coding gene Chr11:75745519-75761218 (-)
PWK/PhJ MGP_PWKPhJ_G0017788
 protein coding gene Chr11:73621037-73634574 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017579
 protein coding gene Chr11:75305470-75317960 (-)
WSB/EiJ MGP_WSBEiJ_G0018070
 protein coding gene Chr11:75554660-75567041 (-)



Homology
more
  • Human Ortholog
    SERPINF1, serpin family F member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINF1, serpin family F member 1
  • Synonyms
    EPC-1, OI12, OI6, PEDF, PIG35
  • Links
    NCBI Gene ID: 5176
    neXtProt AC: NX_P36955
    UniProt: P36955

  • Chr Location
    17p13.3; chr17:1762029-1777565 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Serpinf1 mouse models; 19 with human SERPINF1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Loss of function results in increased microvasculature, pancreatic enlargement, and prostatic hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1106
  • Tissues
    164
  • cDNA Data
    271
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20317 NCBI Gene Model | MGI Sequence Detail 12595 C57BL/6J ±  kb
    transcript NM_011340 RefSeq | MGI Sequence Detail 1497 C57BL/6  
    polypeptide P97298 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 278
      cDNA 274
      Primer pair 1
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23945, MGD-MRK-37117, MGI:103081, MGI:2144083
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 12
      Phenotypes 40
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:348747 Kim G, et al., Gut-liver axis calibrates intestinal stem cell fitness. Cell. 2024 Feb 15;187(4):914-930.e20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory