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Bid Gene Detail
Summary
  • Symbol
    Bid
  • Name
    BH3 interacting domain death agonist
  • Synonyms
    2700049M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:108093
    NCBI Gene: 12122
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:120870080-120894074 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.02 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108093
 protein coding gene Chr6:120868891-120894074 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031211
 protein coding gene Chr6:123810256-123837877 (-)
A/J MGP_AJ_G0031180
 protein coding gene Chr6:119049201-119074324 (-)
AKR/J MGP_AKRJ_G0031111
 protein coding gene Chr6:122268990-122295115 (-)
BALB/cJ MGP_BALBcJ_G0031191
 protein coding gene Chr6:118805504-118831345 (-)
C3H/HeJ MGP_C3HHeJ_G0030909
 protein coding gene Chr6:122287032-122311790 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031649
 protein coding gene Chr6:126982053-127008967 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028809
 protein coding gene Chr6:115945853-115972005 (-)
CAST/EiJ MGP_CASTEiJ_G0030298
 protein coding gene Chr6:122715584-122744403 (-)
CBA/J MGP_CBAJ_G0030874
 protein coding gene Chr6:132023160-132051640 (-)
DBA/2J MGP_DBA2J_G0031030
 protein coding gene Chr6:117934963-117961248 (-)
FVB/NJ MGP_FVBNJ_G0030982
 protein coding gene Chr6:117071950-117098114 (-)
LP/J MGP_LPJ_G0031109
 protein coding gene Chr6:123803033-123833066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031016
 protein coding gene Chr6:135994274-136019447 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031678
 protein coding gene Chr6:122285967-122312877 (-)
PWK/PhJ MGP_PWKPhJ_G0030013
 protein coding gene Chr6:116975180-117003202 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029842
 protein coding gene Chr6:121028792-121053740 (-)
WSB/EiJ MGP_WSBEiJ_G0030381
 protein coding gene Chr6:122578948-122607886 (-)



Homology
more
  • Human Ortholog
    BID, BH3 interacting domain death agonist
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BID, BH3 interacting domain death agonist
  • Synonyms
    FP497
  • Links
    NCBI Gene ID: 637
    neXtProt AC: NX_P55957
    UniProt: P55957

  • Chr Location
    22q11.21; chr22:17734138-17774770 (-)  GRCh38
  • MGI Vertebrate Homology
    Bid stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: BID
  • Protein SuperFamily
    BID
  • Gene Tree
    Bid
Human Diseases
more
  • Diseases
    1 with human BID associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants survive with little or no liver damage after injection with antibody against Fas, whereas mice normally die from hepatocellular apoptosis and hemorragic necrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    900
  • Tissues
    80
  • cDNA Data
    48
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12122 NCBI Gene Model | MGI Sequence Detail 23995 C57BL/6J ±  kb
    transcript NM_007544 RefSeq | MGI Sequence Detail 1907 ZRU/MplStud  
    polypeptide P70444 UniProt | EBI | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 50
      Primer pair 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-37130, MGI:1919829, MGI:2141512, MGI:2141571
    References
    more
    • Summaries
      All 210
      Developmental Gene Expression 24
      Gene Ontology 28
      Phenotypes 100
    • Earliest
      J:36730 Wang K, et al., BID: a novel BH3 domain-only death agonist. Genes Dev. 1996 Nov 15;10(22):2859-69
    • Latest
      J:355539 Abele TJ, et al., Apoptotic signaling clears engineered Salmonella in an organ-specific manner. Elife. 2023 Dec 6;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory